In Vitro and In Vivo Hepatic Differentiation of Adult Somatic Stem Cells and Extraembryonic Stem Cells for Treating End Stage Liver Diseases

Stem Cells International
Chenxia Hu, Lan-Juan Li

Abstract

The shortage of liver donors is a major handicap that prevents most patients from receiving liver transplantation and places them on a waiting list for donated liver tissue. Then, primary hepatocyte transplantation and bioartificial livers have emerged as two alternative treatments for these often fatal diseases. However, another problem has emerged. Functional hepatocytes for liver regeneration are in short supply, and they will dedifferentiate immediately in vitro after they are isolated from liver tissue. Alternative stem-cell-based therapeutic strategies, including hepatic stem cells (HSCs), embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), and mesenchymal stem cells (MSCs), are more promising, and more attention has been devoted to these approaches because of the high potency and proliferation ability of the cells. This review will focus on the general characteristics and the progress in hepatic differentiation of adult somatic stem cells and extraembryonic stem cells in vitro and in vivo for the treatment of end stage liver diseases. The hepatic differentiation of stem cells would offer an ideal and promising source for cell therapy and tissue engineering for treating liver diseases.

References

Jul 8, 1997·Proceedings of the National Academy of Sciences of the United States of America·M D DabevaD A Shafritz
Jul 2, 2003·Human Reproduction·Andrea-Romana PrusaMarkus Hengstschläger
Jan 27, 2005·Biochemical and Biophysical Research Communications·Min Jeong SeoJin Sup Jung
Apr 13, 2005·Biochemical and Biophysical Research Communications·Seung Hyun HongHoeon Kim
Jul 1, 2006·World Journal of Gastroenterology : WJG·Xiao-Peng TangYang Zeng
Dec 26, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Reiichi HigashiyamaIsao Okazaki
Mar 31, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Zhen Fan YangSheung Tat Fan
May 24, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yue YuXue-Hao Wang
Aug 21, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jason ChamberlainGraça Almeida-Porada
Sep 18, 2007·Biochemical and Biophysical Research Communications·Biju ParekkadanMartin L Yarmush
Sep 22, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yoko YoshidaGoshi Shiota
Sep 27, 2007·PloS One·Biju ParekkadanMartin L Yarmush
Nov 17, 2007·Journal of Translational Medicine·Xiaolong MengNeil H Riordan
Apr 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Daan van PollMartin L Yarmush
Jul 16, 2008·Journal of Gastroenterology and Hepatology·Agnieszka BanasTakahiro Ochiya
Aug 30, 2008·Pediatric Hematology and Oncology·Yun-Jae JungHan Ho-Seoung
Nov 1, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Kazuhisa KondoToyoaki Murohara
Jan 15, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Yongmin YanFei Mao
May 9, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Kyung Hee JungSung-Vin Yim
May 29, 2009·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Liang LiangTingbo Liang
Nov 28, 2009·Current Stem Cell Research & Therapy·Tetsuya IshikawaTakahiro Ochiya
Apr 1, 2010·Liver International : Official Journal of the International Association for the Study of the Liver·James LueJeffrey S Glenn
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fabio MarongiuStephen C Strom
Mar 9, 2011·Biochemical and Biophysical Research Communications·Mahboobe GhaediAlexander Revzin
Sep 9, 2011·European Journal of Gastroenterology & Hepatology·Mohie-Eldeen M AmerMohamed Hegazy
Sep 23, 2011·In Vitro Cellular & Developmental Biology. Animal·Hui LiuYang Lv

❮ Previous
Next ❯

Citations

Feb 24, 2016·International Journal of Molecular Sciences·Chenxia HuLanjuan Li
Jan 13, 2019·Journal of Cellular and Molecular Medicine·Chenxia HuLanjuan Li
Apr 20, 2018·Canadian Journal of Gastroenterology & Hepatology·Kyeong-Ah KwakYoung-Seok Park
Nov 21, 2019·World Journal of Gastroenterology : WJG·Pan-Pan CenLan-Juan Li
Jan 6, 2016·Biomedicines·Clara NicolasScott L Nyberg
Feb 26, 2019·Oxidative Medicine and Cellular Longevity·Dong-Dong WuXin-Ying Ji
Jun 15, 2019·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Chenxia Hu, Lanjuan Li
Feb 23, 2020·Biochemistry. Biokhimii︠a︡·N V BobkovaG T Sukhikh
Aug 21, 2020·Acta Parasitologica·Muslimah Alsulami, Rewaida Abdel-Gaber

❮ Previous
Next ❯

Methods Mentioned

BETA
amputations

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Hepatobiliary & Pancreatic Diseases International : HBPD INT
Xu-Bo Wu, Ran Tao
Journal of the Chinese Medical Association : JCMA
Chih-Hung ChiangShou-Dong Lee
Cellular Reprogramming
Virginia Picanço-CastroDimas T Covas
© 2021 Meta ULC. All rights reserved