PMID: 9449280Feb 4, 1998Paper

In vitro and in vivo inhibition of murine gamma herpesvirus 68 replication by selected antiviral agents

Antimicrobial Agents and Chemotherapy
J Neyts, E De Clercq

Abstract

We have evaluated the susceptibility of the murine gamma herpesvirus 68 (MHV-68) to a variety of antiviral agents. The acyclic nucleoside phosphonate analogs cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine], (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA), and adefovir [9-(2-phosphonylmethoxyethyl)adenine] efficiently inhibited the replication of the virus in Vero cells (50% effective concentrations [EC50s], 0.008, 0.06, and 2.2 microg/ml, respectively). Acyclovir, ganciclovir, and brivudin [(E)-5-(2-bromovinyl)-2'-deoxyuridine] had equipotent activities (EC50s, 1.5 to 8 microg/ml), whereas foscarnet and penciclovir were less effective (EC50s, 23 and > or =30 microg/ml, respectively). The novel N-7-substituted nucleoside analog S2242 [7-(1,3-dihydroxy-2-propoxymethyl)purine] inhibited MHV-68 replication by 50% at 0.2 microg/ml. The susceptibilities of MHV-68 and Epstein-Barr virus (EBV) to cidofovir, HPMPA, adefovir, and acyclovir were found to be comparable. However, for penciclovir, ganciclovir, brivudin, and S2242, major differences in the sensitivity of MHV-68 and EBV were observed, suggesting that MHV-68 is not always an optimal surrogate for the study of antiviral strategies for EBV. When evalua...Continue Reading

References

Sep 1, 1992·The Journal of General Virology·N P Sunil-ChandraA A Nash
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Citations

Oct 22, 2002·Journal of Virology·Shivaprakash GangappaHerbert W Virgin
Oct 16, 2004·Expert Review of Anti-infective Therapy·Eric De Clercq
Nov 26, 2014·Viruses·Natacha CoenGraciela Andrei
May 23, 2018·The Journal of Antimicrobial Chemotherapy·Caroline ZeippenLaurent Gillet
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dmitry A YarilinDavid N Posnett
Nov 10, 2010·PloS One·François MichaudJean Gosselin
Nov 16, 2018·Journal of Virology·Kendra A BusseyMelanie M Brinkmann
Apr 21, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A A NashA J Davison
Sep 25, 2004·Medicinal Research Reviews·Erik De Clercq
Nov 16, 2013·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Virginia A FolcikGerard J Nuovo
Oct 6, 2017·European Journal of Immunology·Manon LeBelJean Gosselin
Apr 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emilio FlañoMarcia A Blackman
Oct 1, 2014·Antimicrobial Agents and Chemotherapy·Natacha CoenGraciela Andrei
May 16, 2020·Proceedings of the National Academy of Sciences of the United States of America·Natalia C DrosuDavid E Housman
Aug 19, 2007·Journal of Virology·J Craig ForrestSamuel H Speck
Jun 18, 2021·Multiple Sclerosis and Related Disorders·Natalia DrosuMichael Levy

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