In Vitro and in Vivo Neuroprotective Effects of Walnut (Juglandis Semen) in Models of Parkinson's Disease

International Journal of Molecular Sciences
Jin Gyu ChoiMyung Sook Oh

Abstract

Monoamine oxidase (MAO) catalyzes the oxidative deamination of monoamines including dopamine (DA). MAO expression is elevated in Parkinson's disease (PD). An increase in MAO activity is closely related to age, and this may induce neuronal degeneration in the brain due to oxidative stress. MAO (and particularly monoamine oxidase B (MAO-B)) participates in the generation of reactive oxygen species (ROS), such as hydrogen peroxide that are toxic to dopaminergic cells and their surroundings. Although the polyphenol-rich aqueous walnut extract (JSE; an extract of Juglandis Semen) has been shown to have various beneficial bioactivities, no study has been dedicated to see if JSE is capable to protect dopaminergic neurons against neurotoxic insults in models of PD. In the present study we investigated the neuroprotective potential of JSE against 1-methyl-4-phenylpyridinium (MPP⁺)- or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicities in primary mesencephalic cells and in a mouse model of PD. Here we show that JSE treatment suppressed ROS and nitric oxide productions triggered by MPP⁺ in primary mesencephalic cells. JSE also inhibited depletion of striatal DA and its metabolites in vivo that resulted in signific...Continue Reading

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Citations

Dec 15, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Jin Gyu ChoiMyung Sook Oh
Nov 28, 2019·Oxidative Medicine and Cellular Longevity·Hye-Sun LimGunhyuk Park
May 23, 2018·Nutrients·Małgorzata Kujawska, Jadwiga Jodynis-Liebert
Feb 26, 2020·Nutrients·Abha Chauhan, Ved Chauhan

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Methods Mentioned

BETA
deamination
transgenic
Assay

Software Mentioned

GraphPad Prism
Image J
GraphPad
Chromeleon TM

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