In vitro and in vivo optimization of infrared laser treatment for injured peripheral nerves

Lasers in Surgery and Medicine
Juanita J AndersBrian A Pryor

Abstract

Repair of peripheral nerve injuries remains a major challenge in restorative medicine. Effective therapies that can be used in conjunction with surgical nerve repair to improve nerve regeneration and functional recovery are being actively investigated. It has been demonstrated by a number of peer reviewed publications that photobiomodulation (PBM) supports nerve regeneration, reinnervation of the denervated muscle, and functional recovery after peripheral nerve injury. However, a key issue in the use of PBM as a treatment for peripheral nerve injury is the lack of parameter optimization for any given wavelength. The objective of this study was to demonstrate that for a selected wavelength effective in vitro dosing parameters could be translated to effective in vivo parameters. Comparison of infra-red (810 and 980 nm wavelengths) laser treatment parameters for injured peripheral nerves was done beginning with a series of in vitro experiments using primary human fibroblasts and primary rat cortical neurons. The primary rat cortical neurons were used for further optimization of energy density for 980 nm wavelength light using measurement of total neurite length as the bioassay. For these experiments, the parameters included a 1 W ...Continue Reading

References

Jan 3, 2001·Seminars in Surgical Oncology·G R Evans
Apr 10, 2004·Neurological Research·Juanita J AndersShimon Rochkind
Feb 11, 2005·Lasers in Surgery and Medicine·Kimberly R ByrnesJuanita J Anders
Mar 3, 2005·Muscle & Nerve·Davilene Gigo-BenatoShimon Rochkind
Dec 17, 2008·Neurological Research·Andrew M HartMikael Wiberg
Aug 18, 2009·International Review of Neurobiology·Shimon RochkindAsher Shainberg
Feb 6, 2010·Lasers in Medical Science·Rafael Inácio BarbosaMarisa de Cássia Registro Fonseca
Oct 27, 2010·Lasers in Surgery and Medicine·Davilene Gigo-BenatoNivaldo Antonio Parizotto
May 7, 2011·Lasers in Medical Science·Karla Guivernau Gaudens SerafimCláudia Patrícia Cardoso Martins Siqueira
Oct 19, 2011·Lasers in Surgery and Medicine·Helina MogesJuanita J Anders
Jul 12, 2012·Photomedicine and Laser Surgery·Praveen Ravindra Arany

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Citations

Nov 30, 2014·The Veterinary Clinics of North America. Small Animal Practice·Brian Pryor, Darryl L Millis
Aug 1, 2016·Journal of Photochemistry and Photobiology. B, Biology·Ali Borzabadi-Farahani
Aug 9, 2016·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ann Kobiela KetzJuanita J Anders
Oct 22, 2016·Biochimica Et Biophysica Acta. General Subjects·Yuguang WangMichael R Hamblin
Jan 12, 2017·Lasers in Medical Science·Alireza FallahAmir Saberi Demneh
Oct 25, 2017·Lasers in Medical Science·L AndreoR A Mesquita-Ferrari
Nov 14, 2017·Journal of Neuroscience Research·Michael R Hamblin
May 31, 2017·Photomedicine and Laser Surgery·Daniela Vieira BuchaimRogerio Leone Buchaim
Feb 26, 2019·Neural Regeneration Research·Muhammad Sana Ullah SaharGeoffrey Douglas Tansley
May 4, 2017·Lasers in Medical Science·Enrique VargasF Gonzalez-Lima
May 6, 2019·Photobiomodulation, Photomedicine, and Laser Surgery·Juanita J AndersRaymond J Lanzafame
Apr 4, 2018·Lasers in Medical Science·Luana Gabriel de SouzaRafael Inácio Barbosa
Jul 28, 2020·Surgical Infections·Shawn Tejiram, Jeffrey W Shupp
Mar 21, 2020·Lasers in Medical Science·Mohamed Salaheldien Mohamed AlayatAmir Abdel-Raouf El-Fiky
Dec 4, 2020·Neural Regeneration Research·Muyue YangZhihui Sun
Apr 23, 2021·Journal of Applied Oral Science : Revista FOB·Guilherme José Pimentel Lopes de OliveiraRosemary Adriana Chiérici Marcantonio
Aug 8, 2021·Journal of Photochemistry and Photobiology. B, Biology·Sean P O'ConnorVladislav V Yakovlev

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