In vitro and in vivo oxidative biotransformation in the West-African dwarf goat (Caprus hircus aegagrus): substrate activities and effects of inducers

Xenobiotica; the Fate of Foreign Compounds in Biological Systems
W M Zweers-ZeilmakerR F Witkamp

Abstract

1. Cytochrome P450 activities in vivo and in vitro and enzyme induction by phenobarbital, beta-naphthoflavone, isoniazid and triacetyloleandomycin were investigated in the female dwarf goat. In vivo kinetics of antipyrine, sulphadimidine and caffeine were studied separately and as a combination ("cocktail'). After establishing a lack of interaction between these compounds the effects of the inducing agents were investigated. In vitro, hepatic microsomal enzyme activities and apoprotein levels were determined. 2. In the beta-naphthoflavone treated goat, the microsomal ethoxy-resorufin-O-deethylation rate was markedly increased. beta-naphthoflavone also induced caffeine plasma clearance but did not affect microsomal caffeine 1- and 3-demethylation rates. After phenobarbital treatment, caffeine plasma clearance was also increased. In contrast with beta-naphthoflavone treatment, phenobarbital treatment resulted in an increase of microsomal caffeine 1- and 3-demethylation rates. 3. Goat liver microsomes were able to hydroxylate tolbutamide, predominantly a CYP2C9 activity in man, and debrisoquine, a CYP2D activity in different species. These activities were not affected by either beta-naphthoflavone or phenobarbital. Sulphaphenazole...Continue Reading

References

Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jun 1, 1992·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·F BerthouP H Beaune
Mar 29, 1991·Biochemical and Biophysical Research Communications·M E VeroneseD J Birkett
Dec 1, 1984·Journal of Veterinary Pharmacology and Therapeutics·H van GoghA S van Miert
Apr 15, 1994·Biochemical and Biophysical Research Communications·W M ZeilmakerG J Horbach
Jun 1, 1996·Journal of Veterinary Pharmacology and Therapeutics·W M Zweers-ZeilmakerR F Witkamp

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Citations

Jun 11, 1999·Journal of Applied Toxicology : JAT·C T EasonR Gooneratne
May 23, 1998·Journal of Veterinary Pharmacology and Therapeutics·W M Zweers-ZeilmakerR F Witkamp
Feb 19, 2002·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·H A ElsheikhA K Bashir
May 20, 1999·Research in Veterinary Science·A Anadón, L Reeve-johnson
May 4, 2006·Journal of Veterinary Pharmacology and Therapeutics·G VirkelC Lanusse
Apr 12, 2011·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Kamil UneyBünyamin Traş
Apr 18, 2008·European Journal of Pharmacology·Johanna Fink-Gremmels
May 16, 2001·The Veterinary Journal·A V Miert
Aug 5, 2000·Research in Veterinary Science·K Janus, J Antoszek

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