In vitro and in vivo percutaneous absorption of 14C-octamethylcyclotetrasiloxane (14C-D4) and 14C-decamethylcyclopentasiloxane (14C-D5)

Regulatory Toxicology and Pharmacology : RTP
Marina L JovanovicKathleen P Plotzke

Abstract

Octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) are cyclic siloxanes used as chemical intermediates with some applications in consumer products. The in vitro percutaneous absorption of 14C-D4 and 14C-D5 was studied in flow-through diffusion cells. Single doses were applied neat and in antiperspirant formulations to dermatomed human skin for 24h. The majority of applied D4 and D5 ( approximately 90%) volatilized before being absorbed. Only 0.5% of applied D4 was absorbed while the absorption of D5 (0.04%) was one order of magnitude lower. The largest percentage (>90%) of the absorbed D4 and D5 was found in the skin. The fate of D4 and D5 absorbed in the skin was studied in rat in vivo. A single dose of 14C-D4 (10, 4.8 and 2mg/cm2) and 14C-D5 (10mg/cm2) was topically applied inside a dosing chamber attached to the dorsal area. Rats were housed in metabolism cages up to 24h to enable collection of urine, feces, expired/escaped volatiles. The majority of applied D4 or D5 had volatilized from the skin surface. Less than 1.0% of the applied D4 and only 0.2% of applied D5 was absorbed with approximately 60% of absorbed D4 and 30% of absorbed D5 reaching systemic compartments. The amount absorbed into the skin d...Continue Reading

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Citations

Jul 18, 2015·Regulatory Toxicology and Pharmacology : RTP·Paul A JeanAnthony R Scialli
Jan 3, 2016·Regulatory Toxicology and Pharmacology : RTP·Tami S McMullinMelvin E Andersen
Jun 27, 2015·Regulatory Toxicology and Pharmacology : RTP·Wolfgang Dekant, James E Klaunig
Dec 3, 2014·Environment International·Jacqueline W H BiesterbosPaul T J Scheepers
Dec 30, 2014·The Science of the Total Environment·Tri Manh Tran, Kurunthachalam Kannan
Mar 24, 2009·Chemosphere·Wil ten Berge
Nov 19, 2015·Regulatory Toxicology and Pharmacology : RTP·Allison FranzenKathy Plotzke
Apr 9, 2016·Environment International·Daniela CapelaLúcia Santos
Jan 17, 2017·Toxicology and Industrial Health
Jun 25, 2017·Toxicology Letters·Allison FranzenRobinan Gentry
Jan 25, 2012·International Journal of Toxicology·Wilbur JohnsonF Alan Andersen
Jan 17, 2017·Toxicology and Industrial Health
Apr 30, 2008·Archives of Environmental Contamination and Toxicology·Yuichi Horii, Kurunthachalam Kannan
Aug 23, 2019·Integrated Environmental Assessment and Management·Antonio Franco, Roger van Egmond
Dec 17, 2014·Chemical Reviews·Christoph Rücker, Klaus Kümmerer

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