In Vitro and In Vivo preparation evaluations of bleomycin implants and microspheres Prepared with DL-poly (lactide-co-glycolide)

Drug Development and Industrial Pharmacy
R J D'SouzaN Udupa

Abstract

In this investigation, poly(lactide-co-glycolide) (PLGA) gel implants and microspheric depot systems of bleomycin (BLM) were formulated and evaluated in vivo in mice bearing transplantable solid tumor (fibrosarcoma). The pharmacodynamic studies showed that both the formulations retarded tumor growth significantly (p<0.05) when compared to the control animals (without any drug treatment). Preliminary pharmacokinetic studies illustrated controlled release of the drug into the systemic circulation to elicit the anti-neoplastic action. The gel implants showed better release characteristics and greater pharmacodynamic action when compared to the microspheres, thus demonstrating the feasibility of employing biodegradable depot polymer gel matrix for chronic cancer therapy.

References

Feb 1, 1979·Journal of Pharmaceutical Sciences·G K ShiuW H Pitlick
Jul 1, 1996·The Journal of Pharmacy and Pharmacology·G Chandrashekar, N Udupa
Jan 7, 1999·Drug Development and Industrial Pharmacy·R JainC T Rhodes
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Jun 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·G M ZentnerS Weitman
Oct 18, 2002·Advanced Drug Delivery Reviews·John BarrJorge Heller

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Citations

Oct 20, 2010·International Journal of Molecular Sciences·Heidi M MansourPatrick P Deluca
May 1, 2010·Drug Delivery·Raquel De SouzaMicheline Piquette-Miller
Feb 23, 2019·The Journal of Antimicrobial Chemotherapy·Alexandre MeunierDidier Hocquet

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