PMID: 2111459May 1, 1990Paper

In vitro and in vivo reactions of nucleic acids with reducing sugars

Mutation Research
A T Lee, A Cerami

Abstract

Reducing sugars such as glucose and glucose 6-phosphate have been shown to nonenzymatically react with the amino groups of proteins. The modification of proteins by reducing sugars can alter both physical characteristics and biological functions. Analogous to the reaction observed with proteins, the amino groups of DNA bases are also able to react nonenzymatically with reducing sugars. The modifications of DNA by reducing sugars result in the time- and sugar-concentration-dependent changes in biological properties. In this communication we review data describing in vitro and in vivo models we have used to investigate the biological consequences of the nonenzymatic glycosylation of DNA.

References

Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·A T Lee, A Cerami
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R BucalaA Cerami
Jan 1, 1970·Gerontologia·J J BojanovićD S Jovanović
Mar 5, 1971·Science·G B PriceT Makinodan
Oct 1, 1984·Annals of Internal Medicine·M BrownleeA Cerami
May 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·S PongorA Cerami
Nov 1, 1980·The Journal of Clinical Investigation·S L Schnider, R R Kohn

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Citations

Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·C CeramiA Cerami
Jun 1, 1990·Aging : Clinical and Experimental Research·C Franceschi
Sep 16, 2011·Forensic Science International. Genetics·Reza Alaeddini
Dec 17, 2004·Obesity Research·Jesse RothBarbara C Lowell
Dec 26, 2001·Molecular Biology and Evolution·Richard Ellis HudsonHoward Ochman
May 9, 2006·Journal of the American Veterinary Medical Association·Kelly S Swanson
Apr 12, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nadine NasreddineHakim Hocini
Apr 13, 1999·The American Journal of Physiology·T J WetterG D Cartee
Jul 4, 2012·International Journal of Biological Macromolecules·Jalaluddin M AshrafKhursheed Alam

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