PMID: 8945086Nov 1, 1996Paper

In vitro and in vivo results of transcatheter microwave ablation using forward-firing tip antenna design

Pacing and Clinical Electrophysiology : PACE
L B LiemR Kernoff

Abstract

This study was designed to test a microwave (MW) ablation system using approximately 2,450 MHz of energy and a deflectable catheter with forward-firing tip antenna, an early clinical prototype system. In vitro three-dimensional thermal mapping of single and double helix antenna designs was performed. Quantitative measurements of antenna radiation were recorded on tissue phantoms equipped with temperature sensors distributed radially and outwardly. In vivo testing consisted of closed-chest AV junction ablation in three dogs. Thermal mapping showed hemispherical heat distribution from the tip antenna. For the double helix design, this distribution was measured at 8.4-mm diameter with a maximum temperature of 61.62 degrees C. As expected, the single helix design produced less heating with a measured diameter of 6.4 mm and maximum temperature of 55.90 degrees C. The in vivo study produced lesions of geometry and size concordant with these heating patterns. MW ablation produced bundle branch block in one dog and complete AV nodal block in the remaining two, without transvalvular or other structural damage. The histopathology of the lesions was typical of a thermal burn showing hemorrhage and coagulative necrosis with clearly demarca...Continue Reading

Citations

Dec 22, 1999·Pacing and Clinical Electrophysiology : PACE·P AdragãoR Seabra-Gomes
Feb 16, 2005·IEEE Engineering in Medicine and Biology Magazine : the Quarterly Magazine of the Engineering in Medicine & Biology Society·Laszlo KarolyiBéla Merkely
Dec 31, 1997·Journal of Cardiothoracic and Vascular Anesthesia·L B Liem
May 19, 1998·Pacing and Clinical Electrophysiology : PACE·L B LiemR Kernoff
Apr 5, 2000·Journal of Cardiovascular Electrophysiology·B A VanderBrinkP J Wang

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