In vitro and in vivo ruminal and physiological responses to endophyte-infected tall fescue

Journal of Dairy Science
M L WestendorfR G Powell

Abstract

Relationships between alkaloid compounds in endophyte-infected tall fescue and ruminal metabolism were studied in two experiments. In the first experiment, different combinations of the pyrrolizidine alkaloids, N-formyl and N-acetyl loline, were incubated with ruminal fluid for 0, 24, or 48 h. Rate of disappearance of N-formyl and N-acetyl loline increased over time. After 48 h, disappearance of N-formyl loline and combinations of N-formyl and N-acetyl loline was greater than N-acetyl loline. Significant amounts of N-formyl and N-acetyl loline were metabolized and converted to loline. In the second experiment, abomasally cannulated sheep were fed increasing amounts of endophyte-infected feed to compare diet digestibility, alkaloid metabolism, and physiological responses. Total tract DM digestibility was greatest for the endophyte-free diet, as were ruminal and total tract ADF, ruminal NDF, and total tract CP digestibilities. N-Formyl and N-acetyl loline recoveries averaged 5% from abomasal contents and 0% in feces. Sixty-eight percent of the pyrrolizidine alkaloids recovered in abomasal contents had been metabolizable to loline. Ergot alkaloids administered in the diet were recovered (50 to 60%) in the abomasal contents, but re...Continue Reading

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Citations

Aug 26, 1998·Drug and Chemical Toxicology·A SimeoneG E Mitchell
Mar 5, 2016·Frontiers in Veterinary Science·Stephanie Coufal-MajewskiYuxi Wang
Apr 8, 1998·Drug and Chemical Toxicology·A SimeoneG E Mitchell
Dec 23, 2008·Journal of Animal Science·G B HuntingtonJ Burns
Apr 6, 2017·Journal of Animal Science·B E HarlowG E Aiken
Feb 8, 2011·Journal of Animal Science·J L KlotzJ R Strickland
Nov 27, 2018·Journal of Animal Science·Ronald J TrottaJames L Klotz
Apr 23, 2011·Journal of Animal Science·A P FooteJ L Klotz
Feb 10, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Javier EspinozaEmilio Ungerfeld

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