In vitro and in vivo stability investigations of Cu(II), Zn(II), Ca(II) and Gd(III) complexes with N,N'-bis(2-hydroxyiminopropionyl) propane-1,3-diamine

Dalton Transactions : an International Journal of Inorganic Chemistry
Edmund T NomkokoBandile S Nakani

Abstract

Formation constants of copper(II), zinc(II), calcium(II) and gadolinium(III) with N,N'-bis(2-hydroxyiminopropionyl) propane-1,3-diamine (L2) have been studied at 25 degrees C and an ionic strength of 0.15 mol dm(-3). The reasonably high formation constants of the copper with this ligand are due to the ease with which the metal ion deprotonates the amide moieties. The square-planar coordination of L2 towards copper as predicted from UV-visible data may also account for the high selectivity of L2 towards the metal ion. Octanol/water partition coefficients of Cu(II)-L2 complexes indicate that although these complexes are largely hydrophilic, approximately 1.86% of the [CuL2H(-1)] species goes into the octanol layer and hence may promote dermal absorption of copper with a calculated penetration rate of 1.24 x 10(-5) cm h(-1). The [CuL2H(-1)] complex which predominates at pH 7.4 is a poor mimic of native copper-zinc superoxide dismutase. Blood-plasma simulation studies predict that, despite the high concentration of zinc and calcium in vivo, L2 is able to increase the low-molecular-mass fraction of copper. Biodistribution experiments using 64Cu-labelled [CuL2H(-1)] indicate an initial high uptake of this species in the liver, but it...Continue Reading

References

Jun 1, 1994·The Journal of Membrane Biology·T X Xiang, B D Anderson
Apr 12, 1997·Biochimica Et Biophysica Acta·R W KinneF Emmrich
Sep 29, 1998·Nuclear Medicine and Biology·T M Jones-WilsonM J Welch
Sep 29, 1998·Nuclear Medicine and Biology·A B PackardS T Treves
Jul 17, 2001·Annals of the Rheumatic Diseases·H LindegaardM Østergaard
Jul 15, 2004·Dalton Transactions : an International Journal of Inorganic Chemistry·Thembelani E NomkokoJan R Zeevaart
Nov 1, 2001·European Journal of Nuclear Medicine·A SignoreF Scopinaro

❮ Previous
Next ❯

Citations

Oct 26, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Graham E JacksonRaffaele P Bonomo
Nov 20, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Ru-Xia ZhangHong-Ling Gao
Mar 7, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·Sebusi OdisitseAmith Singh

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.