In vitro and in vivo studies of the effect of artemether on Schistosoma mansoni.

Antimicrobial Agents and Chemotherapy
S Xiao, B A Catto

Abstract

To determine whether artemether, a derivative of the antimalarial agent qinghaosu, is therapeutically active against Schistosoma mansoni, we determined the in vitro, in vivo, and histopathologic effects of the drug on S. mansoni worms. In vitro, toxic effects of artemether on S. mansoni were not seen at concentrations of less than 100 micrograms/ml. However, in vivo, 30 and 50% reductions in the lengths of male and female worms, respectively, were observed 14 days after treatment. By 56 days worm dimensions had returned to control values. Similar reversible effects on male testes and female ovaries were seen. In vivo, a single oral dose of artemether (300 mg/kg) induced a shift of worms towards the liver within 8 h after treatment. By 3 and 14 days after treatment, 99 and 76%, respectively, of worms were still in the liver. In vivo, the therapeutic effect of artemether on adult S. mansoni treated on day 56 after infection was modest. Doses as high as 1,200 mg (200 mg/kg per day, six doses) resulted in a worm reduction rate of only 39%. However, in infected mice treated on day 14 or 21 after infection, worm reduction rates of 83 to 98% were obtained. Thus, artemether exhibited modest in vitro and in vivo activities against adult...Continue Reading

References

Jan 1, 1987·Transactions of the Royal Society of Tropical Medicine and Hygiene·S R Krungkrai, Y Yuthavong
Jun 1, 1985·The Journal of Infectious Diseases·S H XiaoL T Webster
Jan 1, 1983·Transactions of the Royal Society of Tropical Medicine and Hygiene·Z L LiW Peters
Nov 1, 1987·Parasitology Today·G C ColesN Katz
Aug 1, 1988·Parasitology Today·H L CallahanE R James

❮ Previous
Next ❯

Citations

Oct 19, 1990·Pharmaceutisch Weekblad. Scientific Edition·H J WoerdenbagN Pras
Mar 4, 2009·Parasitology Research·Rashad Abdul-GhaniAzza Hassan
Mar 5, 2013·Parasitology Research·Naglaa Mohamed El-Lakkany, Sayed Hassan Seif El-Din
Jun 1, 2005·Parasitology International·Wannee JiraungkoorskulNiwat Kangwanrangsan
Mar 5, 2003·Experimental Parasitology·Shu-Hua XiaoJürg Utzinger
Sep 12, 2000·International Journal for Parasitology·S XiaoM Tanner
Dec 4, 2001·International Journal for Parasitology·J UtzingerM Tanner
Apr 5, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·D De ClercqM Diop
Mar 31, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·S XiaoM Tanner
Aug 15, 2002·Transactions of the Royal Society of Tropical Medicine and Hygiene·Jürg UtzingerMarcel Tanner
Oct 17, 2006·Parasitology Today·D Cioli
Mar 27, 2001·Veterinary Parasitology·H J Youn, J W Noh
Dec 26, 2001·Veterinary Parasitology·Jong-Tai KimHee-Jeong Youn
Jul 11, 2012·Organic & Biomolecular Chemistry·Don Antoine LanfranchiElisabeth Davioud-Charvet
May 19, 2010·Antimicrobial Agents and Chemotherapy·Rashika El RidiOmar M Fahmy
Jun 1, 1991·Antimicrobial Agents and Chemotherapy·S Merali, S R Meshnick
Apr 24, 2003·Antimicrobial Agents and Chemotherapy·Jürg UtzingerBurton H Singer
Jan 12, 2007·PLoS Medicine·Maha-Hamadien AbdullaConor R Caffrey
Jul 17, 2008·PLoS Neglected Tropical Diseases·Malcolm K JonesAlex Loukas
Jan 1, 2009·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·H B JatsaP Kamtchouing
Jun 21, 2014·Parasitology Research·Jian XueShu-hua Xiao
Oct 1, 2007·Expert Opinion on Drug Discovery·Jennifer Keiser, Jürg Utzinger
Feb 24, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mohamed E M SaeedThomas Efferth
Sep 2, 2008·Travel Medicine and Infectious Disease·Luc Van NassauwJozef Vercruysse
Jan 25, 2014·Journal of Travel Medicine·Liliana PraticòGuido Chichino
Oct 29, 2003·Trends in Parasitology·Alan FenwickMatthew H Todd
Jan 18, 2006·Experimental Parasitology·Wannee JiraungkoorskulNiwat Kangwanrangsan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Anthelmintics (ASM)

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.