PMID: 8997652Dec 1, 1996Paper

In vitro and in vivo studies on salifluor/PVM/MA copolymer/NaF combination as an antiplaque agent

Journal of Clinical Periodontology
N NabiA Gaffar

Abstract

Salifluor (5-n-octanoyl-3'-trifluoromethyl-salicylanilide), a broad spectrum antimicrobial agent, was investigated for its ability to inhibit dental plaque formation. A combination of salifluor with PVM/MA copolymer and NaF was optimized for its antiplaque effect in mouthrinse and dentifrice formulations based on a series of both laboratory and clinical studies. It was found that salifluor, a highly hydrophobic compound, could not be adequately solubilized with the conventional amount of sodium lauryl sulfate (SLS), the most commonly used anionic surfactant in oral hygiene products. However, it was possible to prepare stable mouthrinse formulations using a mixed surfactant system containing both anionic and nonionic surfactants. The most suitable mixture was found to be a combination of SLS, Pluronic and Tauranol in a proportion of 1:1:1. This combination provided adequate stability and high antimicrobial activity as determined by in vitro microbiological tests. Addition of a PVM/MA copolymer to the formulation improved the adsorption and retention of salifluor on stimulated tooth surfaces in vitro (saliva coated hydroxyapatite disks) by almost two-fold and also increased the antiplaque efficacy in both laboratory and human cli...Continue Reading

References

Dec 1, 1979·Journal of Clinical Periodontology·H Löe
Aug 1, 1992·Journal of Clinical Periodontology·P RambergA Gaffar
Nov 1, 1989·Clinical Oncology : a Journal of the Royal College of Radiologists·W H WallaceH R Gattamaneni
Apr 1, 1989·Journal of Autoimmunity·E CrainD B Drachman
Mar 1, 1987·Journal of Clinical Periodontology·C A SaxtonF van der Ouderaa
Nov 1, 1986·Journal of Clinical Periodontology·M Addy
Jan 1, 1986·Journal of Medicinal Chemistry·M T ClarkR J Genco
Jan 1, 1966·Journal of Periodontal Research·E TheiladeH Löe
Jan 1, 1970·Journal of Periodontal Research·P GjermoG Rölla
Jan 1, 1970·Journal of Periodontology·S TureskyI Glickman
Nov 1, 1994·Journal of Dental Research·S HerlesA Gaffar
Aug 1, 1994·Scandinavian Journal of Dental Research·V KjaerheimG Rölla
Feb 1, 1994·Scandinavian Journal of Dental Research·S M WaalerV Kjaerheim
May 1, 1965·Journal of Periodontology·H LOES B JENSEN
Jul 1, 1962·The Journal of the American Dental Association·G A QUIGLEY, J W HEIN

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Citations

Oct 24, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Ye Jin, Hak-Kong Yip
Feb 8, 2000·The Journal of Antimicrobial Chemotherapy·C van LoverenJ M ten Cate

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