In vitro and in vivo study on the antioxidant activity of dexrazoxane

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Fabio GalettaGino Santoro

Abstract

The iron chelator dexrazoxane has been shown to significantly reduce anthracycline-induced cardiac toxicity in several randomized controlled studies. Aim of the present study was to assess the in vitro and in vivo antioxidant effects of dexrazoxane. The in vitro antioxidant activity of dexrazoxane as its total oxyradical scavenging capacity (TOSC) was assessed and compared to that of some classic antioxidants such as reduced glutathione (GSH), uric acid and trolox. The plasma antioxidant activity of 20 newly-diagnosed non-Hodgkin lymphoma (NHL) patients scheduled to receive anthracycline-containing chemotherapy (ProMECE-CytaBOM) was also evaluated. Results were expressed as TOSC units. Dexrazoxane exhibited an in vitro scavenging capacity towards hydroxyl radicals 320% higher than that of GSH (p<0.00001), 20% higher than that of uric acid (p<0.001), and 100% higher than that of trolox (p<0.001). In the clinical study, ProMECE-CytaBOM infusion significantly reduced plasma TOSC in NHL patients (p=0.0001). Dexrazoxane supplementation was able to restore plasma antioxidant activity in two hours from the end of the ProMECE-CytaBOM infusion. Dexrazoxane has in vitro antioxidant capacity. In vivo, it is able to reduce the epirubicin-i...Continue Reading

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Dec 6, 2005·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fabio GalettaGino Santoro

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Citations

Sep 25, 2015·Mutagenesis·Sabry M AttiaSaleh A Bakheet
Mar 21, 2012·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·G F DraenertW Wagner
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Mar 10, 2016·Journal of Cardiothoracic and Vascular Anesthesia·Adriana D OpreaMaysa Abu-Khalaf
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Walter Lemmo
Oct 4, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Sabry M AttiaSaleh A Bakheet
Oct 17, 2018·Journal of the Science of Food and Agriculture·Manuela GrčevićOlivera Galović
May 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Laure-Anne PeyratNikolas Fokialakis
Mar 24, 2012·Canadian Journal of Physiology and Pharmacology·Libuše ZatloukalováRadomír Hrdina
Jan 16, 2020·Antioxidants·Federica De LazzariMarco Bisaglia
Sep 7, 2019·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·Qing-Hu WangJun-Sheng Hao

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