PMID: 15851907Apr 27, 2005

In vitro and in vivo: the story of nonoxynol 9

Journal of Acquired Immune Deficiency Syndromes : JAIDS
Sharon HillierFulvia Veronese

Abstract

There is an urgent need to expand the range of interventions to prevent HIV transmission and acquisition, especially those that can be controlled by women. Microbicides, defined as antimicrobial products that can be applied topically for the prevention of HIV and other sexually transmitted infections, may offer one of the most promising preventive interventions, because they could be inexpensive, readily available, and widely acceptable. The first microbial product to be clinically evaluated contained Nonoxynol-9 (nonylpenoxypolyethoxyethanol [N-9]), a nonionic surfactant, as the active agent. This article presents a review of the in vitro, ex vivo, and animal model data on the safety of N-9 and a critical analysis of their predictive power based on the results of multiple safety and efficacy trials.

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Related Concepts

Acquired Immunodeficiency Syndrome
Clinical Trials
Tensides
Nonoxynol, 4-Sulfate, Ammonium Salt
Anti-HIV Agents

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