In vitro and in vivo toxicity of T-2 toxin, a Fusarium mycotoxin, to mouse peritoneal macrophages.

Infection and Immunity
D Vidal, S Mavet

Abstract

The effects of T-2 toxin on mouse peritoneal macrophages were investigated. Scanning electron microscopy of macrophages treated in vitro with T-2 toxin revealed retraction of pseudopodia. Protein synthesis was inhibited after in vitro contact with T-2 toxin but was not affected 24 h after injection of a sublethal dose of toxin into mice. There was reduction in the phagocytosis of Pseudomonas aeruginosa when macrophages were exposed in vitro to T-2 toxin and when mice were injected with T-2 toxin. Clearance of colloidal carbon was not modified after T-2 toxin injection, whereas spleen weight was decreased 24 h after T-2 injection. T-2 toxin enhanced the mortality of mice infected with Salmonella typhimurium C5S when it was administered 24 h prior to oral challenge with the bacterium.

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Citations

Jun 24, 2014·Immunopharmacology and Immunotoxicology·Jafar SalimianNajmeh Poursasan
Oct 13, 2020·Frontiers in Neuroscience·Nazanin MirzaeiMaya Koronyo-Hamaoui
Nov 21, 2017·Archives of Toxicology·Qinghua WuKamil Kuca
Oct 1, 1994·Clinical Microbiology Reviews·P E NelsonE J Anaissie

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