In vitro and in vivo validation of time domain velocity and flow measurement technique

Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine
D MaulikC Phillips

Abstract

This study was undertaken to validate the time domain processing method for measuring (1) the peak velocity in comparison to pulsed-wave spectral Doppler findings in an in vitro system; (2) the volumetric flow in comparison to the actual flow measured by a graduated cylinder in an in vitro circulation; and (3) the volumetric flow in comparison to a transit time flowmeter in a permanently instrumented neonatal lamb model. A prototype implementation of time domain processing in a commercial ultrasound device was used. For velocimetry, both time domain processing and Doppler methods showed low variance, low intrarater variability (0.03 and 0.09%, respectively), high reliability coefficients (97% and 96%, respectively), and a significant correlation (r = 0.96; P < 0.001). For in vitro flow quantification, time domain processing and graduated cylinder methods showed low variance, low intrarater variability (0.09 and 0.01%, respectively), high reliability coefficients (99.60% and 99.96%, respectively), and a significant correlation (r = 0.98, P < 0.001). For in vivo flow quantification, time domain processing and transit time flowmeter showed a significant correlation (r = 0.96; P < 0.001). Within the limits of the in vitro and in vi...Continue Reading

Citations

Jun 3, 2000·Stroke; a Journal of Cerebral Circulation·S S Ho, C Metreweli
Feb 25, 2005·AJR. American Journal of Roentgenology·S S Y HoC Metreweli
Jan 1, 2004·Neuromodulation : Journal of the International Neuromodulation Society·Francisco RobainaJesús Morera
Jun 21, 2003·Journal of Neurosurgery·Bernardino ClavoMaria A Hernández

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