In vitro androgenicity in pulp and paper mill effluents

Environmental Toxicology
Anders Svenson, Ann-Sofie Allard

Abstract

Pulp and paper mill effluents were examined for in vitro androgenicity using a recombinant yeast-based androgen receptor assay. Low levels of androgenic effects were detected in extracts of some effluents after activated sludge treatment. Yeast cell growth cell was inhibited in some samples, and this interfered with the androgenic response. Solid-phase fractionation revealed androgenicity after partial separation of components in the effluents. Comparison of levels in untreated effluent and in effluent treated in an aerated lagoon showed that this treatment had only a marginal effect on androgenicity. An assay of the fractions eluted with increasing concentrations of methanol showed that androgenic compounds were low to moderately lipophilic. In an attempt to identify these compounds, a number of wood-related compounds (guaiacol, vanillin, beta-sitosterol, betulin, pinosylvin-O-methyl ether, and a wood extract enriched in lignans) were examined but were found not to be androgenic. Raw process water was not androgenic, but water from a highly humified lake and process water from the production of pulp from partly decayed wood had low androgenicity. It therefore can be plausibly suggested that the androgens originated in decaying...Continue Reading

References

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Citations

Jul 11, 2006·Archives of Environmental Contamination and Toxicology·Stefan OrnLeif Norrgren
Dec 4, 2013·Archives of Environmental Contamination and Toxicology·Tomas HanssonBengt-Erik Bengtsson
May 7, 2009·Analytical and Bioanalytical Chemistry·Jana M WeissMarja H Lamoree
Apr 9, 2008·Ecotoxicology and Environmental Safety·Isabel R BarbosaAmadeu M V M Soares
Jun 6, 2013·Environmental Science. Processes & Impacts·Dehua MaRui Lui

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