Jan 1, 1975

In vitro antagonism of the mediators of allergy by a benzopyrano-benzopyran carboxylic acid PR-D-92-EA

International Archives of Allergy and Applied Immunology
G J PossanzaP B Stewart

Abstract

PR-D-92-EA was tested on isolated guinea pig ileum and rat stomach strips for activity against mediators probably released after allergen antibody union. It antagonized the response produced by histamine, bradykinin, serotonin, prostaglandin E2, prostaglandin F2ALPHA and slow-reacting substance of anaphylaxis (SRS-A). The concentrations which blocked 50% of the response were 150, 145, 92, 70, 47, and 32 mug/ml, respectively. This compound may be useful in the treatment of allergic conditions.

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Mentioned in this Paper

Benzopyrans
Lung
Anti-Inflammatory Agents
Ileum
Myopathy
Antihistamines, Classical
Anaphylaxis
Inotropism
Serotonin Antagonists
Anthropoidea

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