PMID: 336Jan 1, 1975

In vitro antagonism of the mediators of allergy by a benzopyrano-benzopyran carboxylic acid PR-D-92-EA

International Archives of Allergy and Applied Immunology
G J PossanzaP B Stewart


PR-D-92-EA was tested on isolated guinea pig ileum and rat stomach strips for activity against mediators probably released after allergen antibody union. It antagonized the response produced by histamine, bradykinin, serotonin, prostaglandin E2, prostaglandin F2ALPHA and slow-reacting substance of anaphylaxis (SRS-A). The concentrations which blocked 50% of the response were 150, 145, 92, 70, 47, and 32 mug/ml, respectively. This compound may be useful in the treatment of allergic conditions.


Jul 15, 1977·European Journal of Pharmacology·J F Burka, P Eyre
Oct 1, 1979·British Journal of Pharmacology·N Chand, P Eyre

Related Concepts

Anti-Inflammatory Agents
Bradykinin Hydrochloride
Carboxylic Acids
Dose-Response Relationship, Drug
Cavia porcellus
Antihistamines, Classical

Related Feeds


Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.