In Vitro Anthelmintic Activity of Saponins from Medicago spp. Against Sheep Gastrointestinal Nematodes

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Michela MaestriniStefania Perrucci

Abstract

Gastrointestinal strongyle nematodes (GIS) are included among the most important parasites of small ruminants. The widespread drug resistance and drug residues in products of animal origin have increased the interest in the search for natural compounds with anthelmintic activity as a valid alternative to current synthetic drugs. The aim of the present investigation was to test the 'in vitro' anthelmintic activity of saponins and prosapogenins from different Medicago species, selected for their importance as a forage crop worldwide for animal feeding. From these plants, saponin mixtures were extracted, purified and used at scalar concentrations to evaluate their anthelmintic activities against sheep gastrointestinal strongyles (GISs), by the egg hatch test. Treated and untreated controls were used as the comparison. Data were statistically analyzed, and EC50 and EC90 were also calculated. All saponins and prosapogenins showed inhibiting effects on GIS eggs in a concentration-dependent manner. At higher concentrations, most of them showed an efficacy comparable to the reference drug (Thiabendazole 3 µg/mL) (P < 0.001). With 1.72 mg/mL EC50 and 3.84 mg/mL EC90, saponin from M. polymorpha cultivars Anglona was the most active. Obta...Continue Reading

References

Dec 20, 1999·Journal of Agricultural and Food Chemistry·Z BialyC Pizza
Aug 25, 2004·Journal of Ethnopharmacology·S G SpargJ van Staden
Dec 22, 2005·Journal of Agricultural and Food Chemistry·Aldo TavaMarian Jurzysta
Jan 24, 2006·Veterinary Parasitology·G C ColesJ Vercruysse
Mar 30, 2006·Journal of Agricultural and Food Chemistry·Zbigniew BialyAldo Tava
Apr 19, 2006·Phytotherapy Research : PTR·Pinarosa AvatoMarian Jurzysta
Mar 29, 2011·Veterinary Parasitology·M M Hernández-VillegasM Cáceres-Farfan
Apr 30, 2011·Journal of Agricultural and Food Chemistry·Aldo TavaPinarosa Avato
Apr 17, 2012·Veterinary Parasitology·E PapadopoulosS Ptochos
Apr 24, 2012·Veterinary Parasitology·J F J Torres-AcostaJ A Cuéllar-Ordaz
Jun 4, 2014·Trends in Parasitology·Johannes CharlierJozef Vercruysse
Nov 2, 2014·Journal of Agricultural and Food Chemistry·Pamela AbbruscatoAldo Tava
Jun 16, 2016·Journal of Veterinary Pharmacology and Therapeutics·J H WhittakerM T Brewer
Aug 6, 2016·Journal of Natural Medicines·Nhu Ngoc Quynh VoToshiya Muranaka
Mar 4, 2017·Phytochemistry·Aldo TavaPinarosa Avato
Nov 11, 2017·Transboundary and Emerging Diseases·J CharlierE Claerebout
May 22, 2018·Parasitology·Acidália Carine Vieira SantosMaria José Moreira Batatinha
Sep 12, 2018·Veterinary Sciences·Federica GiovanelliStefania Perrucci
Jan 2, 2019·Ecotoxicology and Environmental Safety·Ivan VokřálSkálová Lenka
Jan 12, 2019·Experimental Parasitology·J A Cortes-MoralesA Zamilpa
Jan 25, 2019·Research in Veterinary Science·Myriam Esteban-BallesterosMaría Martínez-Valladares
Jan 27, 2019·PloS One·Dyego Gonçalves Lino BorgesFernando de Almeida Borges

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Citations

Apr 8, 2020·Plants·Trifone D'AddabboPinarosa Avato
Oct 8, 2020·Animals : an Open Access Journal From MDPI·Rafael Arturo Torres-FajardoJuan Felipe de Jesús Torres-Acosta
Nov 21, 2020·Tropical Animal Health and Production·Muhammad NaeemNabila Roohi
Jun 15, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Guanzhen WangChunpeng Wan
Sep 2, 2021·Parasite : Journal De La Société Française De Parasitologie·Michela MaestriniStefania Perrucci

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Statistical Analysis System ( SAS )
XLSTAT

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