In vitro anti-adhesive activity of an acidic polysaccharide from Panax ginseng on Porphyromonas gingivalis binding to erythrocytes

Planta medica
Ji-Hye LeeKyung Hyun Kim

Abstract

A polysaccharide with high uronic acid content from the roots of Panax ginseng was found to inhibit the ability of Porphyromonas gingivalis to agglutinate erythrocytes. This polysaccharide showed a strong inhibitory activity (minimum inhibitory concentration 0.25 mg/mL), but treatment with pectinase resulted in non-inhibitory hydrolyzed products. In contrast, the inhibition by the acidic polysaccharide from the leaves of Artemisia capillaris was negligible. The carbohydrate composition of the two polysaccharides indicated that the anti-adhesive activity may be correlated with glucuronic acid content, one of the components of glycosaminoglycans. Low molecular weight heparin and sucrose octasulfate revealed stronger inhibitory effects on bacterial binding, than the acidic polysaccharide from P. ginseng.

Citations

Mar 28, 2008·Archives of Pharmacal Research·Min Cheol YangKang Ro Lee
Jan 25, 2011·Critical Reviews in Microbiology·V H TournasE J Katsoudas
Jun 27, 2012·Environmental Microbiology·Olaya RenduelesJean-Marc Ghigo
Nov 12, 2014·International Journal of Molecular Medicine·Paulo José Lima JuizMario Julio Avila-Campos
Mar 3, 2012·Chemical & Pharmaceutical Bulletin·Noriaki FukuyamaYutaka Orihara

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