In vitro anti-aging activities of Terminalia chebula gall extract

Pharmaceutical Biology
Aranya ManosroiJiradej Manosroi

Abstract

The Thai Lanna region has its own folklores and wisdoms in various fields such as traditional medicines. The galls of Terminalia chebula Retz. (Combretaceae) frequently appear in many Thai Lanna medicinal plant recipes for promoting longevity. To investigate the in vitro anti-aging activities of the extracts from 15 plants including T. chebula gall selected from the Thai medicinal plant recipes that have been traditionally used for longevity. The plant extracts were prepared by four extraction methods including hot (HW) and cold (CW) aqueous processes and hot (HM) and cold (CM) methanol processes. These extracts were tested for antioxidative and tyrosinase inhibition activity as well as the proliferative and MMP-2 inhibition activity on early aging human skin fibroblasts in order to evaluate their in vitro anti-aging activity. At 0.1 mg/mL, the CW extract of T. chebula gall exhibited the highest DPPH radical scavenging activity with scavenging of 84.64% +/- 2.22%, whereas ascorbic acid, alpha-tocopherol and butylated hydroxyl toluene gave 96.50% +/- 0.1%, 35.74% +/- 0.2% and 27.43% +/- 0.1%, respectively. The CW extract of T. chebula gall indicated the highest stimulation index (SI) on normal human fibroblast proliferation of 1...Continue Reading

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Citations

Mar 5, 2016·Advances in Pharmacological Sciences·Amir R AfshariHamid Mollazadeh
Nov 26, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Pulok K MukherjeeBirendra K Sarkar
Nov 29, 2014·Pharmaceutical Biology·Jiradej ManosroiAranya Manosroi
Aug 14, 2013·Chemistry & Biodiversity·Aranya ManosroiToshihiro Akihisa
Aug 20, 2020·International Journal of Cosmetic Science·Jiradej ManosroiAranya Manosroi
Jun 21, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Diana I S P ResendeMadalena M M Pinto

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