In vitro anti-diabetic effects and phytochemical profiling of novel varieties of Cinnamomum zeylanicum (L.) extracts

PeerJ
W A Niroshani M WariyapperumaBimali Jayawardena

Abstract

Diabetes mellitus type 2 (DMT2) is a leading metabolic disorder in the world. Anti-diabetic actions of phytochemicals from various medicinal herbs have been explored as an alternative therapy in the management of DMT2 due to adverse effects of synthetic drugs used in allopathic medicine. α-amylase and α-glucosidase inhibitory potential and phytochemical profiling were investigated in aqueous extracts of two new Cinnamomum zeylanicum accessions, namely C. zeylanicum Sri Wijaya (SW), C. zeylanicum Sri Gemunu (SG) and commercially available C. zeylanicum (CC). Microwave Digestion (MD), Pressurized Water Extraction (PWE), Steam Distillation (SD), Solvent Extraction (SE), Decoction Water Extraction (DWE) and Infusion Water Extraction (IWE) methods were used to prepare Cinnamon quill extracts. Total phenolic content (TPC, Folin-Ciocalteu method) and Proanthocyanidin content (PC, vanillin assay), α-amylase and α-glucosidase inhibition of Cinnamon extracts were determined spectrophotometrically. The α-amylase and α-glucosidase inhibition were reported in terms of IC50 value. The phytochemical profiling was accomplished by GC-MS technique. Lowest IC50 values were observed in PWE and DWE of SW. The highest PC and TPC were also observed i...Continue Reading

References

Jul 22, 1997·International Journal of Food Microbiology·B OuattaraA Bégin
Nov 25, 2003·Diabetes Care·Alam KhanRichard A Anderson
Apr 6, 2007·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Gurdip SinghCesar A N Catalan
Jan 1, 2008·Vascular Health and Risk Management·Floris Alexander van de Laar
Mar 25, 2010·Phytochemical Analysis : PCA·Bimali Jayawardena, Roger M Smith
Nov 24, 2011·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Poonam G DaswaniTannaz J Birdi
Mar 15, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Rahman M HafizurRehan A Siddiqui
Nov 12, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Hilal ZaidFatma U Afifi
Sep 17, 2016·Asian Pacific Journal of Tropical Medicine·Mohammad Rahimi-MadisehMahmoud Rafieian-Kopaei
Jun 14, 2017·Acta Biologica Hungarica·István TakácsGyöngyi Gyémánt

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