PMID: 8585758Sep 1, 1995Paper

In vitro anti-HIV-1 activity of HIV protease inhibitor KNI-272 in resting and activated cells: implications for its combined use with AZT or ddI

Antiviral Research
S ChokekijchaiH Mitsuya

Abstract

KNI-272, a conformationally constrained human immunodeficiency virus (HIV) protease inhibitor containing a P1 allophenylnorstatine (Apns) ((2S,3S)- 3-amino-2-hydroxy-4-phenylbutyric acid), has been shown to be a selective and potent inhibitor of the replication of a wide spectrum of HIV strains in vitro. When KNI-272 was tested in combination with 3'-azido-2',3'-dideoxythymidine (AZT) or 2',3'-dideoxyinosine (ddI) against a primary HIV-1 isolate in phytohemagglutin-activated peripheral blood mononuclear cells (PHA-PBM), its activity was identified to be additive, but not synergistic or antagonistic, as analyzed with the COMBO program package. When tested alone for anti-HIV-1 activity in resting PBM (R-PBM) and PHA-PBM, KNI-272 was found to be comparably potent against the virus in both target cell populations, whereas AZT was more potent in PHA-PBM than in R-PBM and ddI was more potent in R-PBM. These data suggest a potential clinical application of KNI-272 and its analogs.

References

Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P AshornE A Berger
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R L DesJarlaisC S Craik
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P AshornB Moss
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·S D MalleyJ R Vila
Jun 1, 1994·AIDS Research and Human Retroviruses·S KageyamaH Mitsuya
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·T ShirasakaH Mitsuya

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.