In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens

Bioorganic & Medicinal Chemistry Letters
Jae Yeon KimJae-Ha Ryu

Abstract

Four flavones, 3,4'-O-dimethylquercetin (1), 3,7-O-dimethylquercetin (2), 3-O-methylquercetin (3) and 3,7,4'-O-trimethylquercetin (4) were isolated as the inhibitors of nitric oxide production in activated microglia (IC(50) values: 11.1, 4.2, 3.8, and 25.1 microM, respectively). They suppressed the expression of protein and mRNA of inducible nitric oxide synthase. Furthermore, compounds 2 and 3 showed scavenging activity of peroxynitrite with SC(50) values of 1.75 and 0.77 microM, respectively.

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Citations

Aug 4, 2010·Molecules and Cells·Eun Ji JoeJoong-Hoon Ahn
Mar 25, 2011·Critical Reviews in Food Science and Nutrition·R GonzálezF Sánchez de Medina
Jun 3, 2014·Biological & Pharmaceutical Bulletin·Ronghui GuChunlin Long
Jun 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Joana PintoArtur M S Silva
Jul 23, 2016·Mediators of Inflammation·Fernanda Paula R SantanaCarla M Prado
Apr 9, 2014·The American Journal of Chinese Medicine·Ha Neul LeeDong-Wan Seo
Dec 31, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jae-Myung YooJin Yeul Ma
Mar 18, 2017·Bioorganic & Medicinal Chemistry Letters·Jianbin WangHongzheng Fu
Feb 19, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qian WuJae-Ha Ryu
Nov 8, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Camila CamponogaraSara Marchesan Oliveira

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