In vitro anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A, a chalcone isolated from Boesenbergia rotunda (L.) (fingerroot).

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
N M IsaM R Mustafa

Abstract

The current in vitro study was designed to investigate the anti-inflammatory, cytotoxic and antioxidant activities of boesenbergin A (BA), a chalcone derivative of known structure isolated from Boesenbergia rotunda. Human hepatocellular carcinoma (HepG2), colon adenocarcinoma (HT-29), non-small cell lung cancer (A549), prostate adenocarcinoma (PC3), and normal hepatic cells (WRL-68) were used to evaluate the cytotoxicity of BA using the MTT assay. The antioxidant activity of BA was assessed by the ORAC assay and compared to quercetin as a standard reference antioxidant. ORAC results are reported as the equivalent concentration of Trolox that produces the same level of antioxidant activity as the sample tested at 20 µg/mL. The toxic effect of BA on different cell types, reported as IC50, yielded 20.22 ± 3.15, 10.69 ± 2.64, 20.31 ± 1.34, 94.10 ± 1.19, and 9.324 ± 0.24 µg/mL for A549, PC3, HepG2, HT-29, and WRL-68, respectively. BA displayed considerable antioxidant activity, when the results of ORAC assay were reported as Trolox equivalents. BA (20 µg/mL) and quercetin (5 µg/mL) were equivalent to a Trolox concentration of 11.91 ± 0.23 and 160.32 ± 2.75 µM, respectively. Moreover, the anti-inflammatory activity of BA was signific...Continue Reading

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Citations

Oct 16, 2014·International Journal of Molecular Sciences·Jian-Zhang WuPei-Hong Qiu
May 16, 2017·Pharmacognosy Reviews·Oranun Ongwisespaiboon, Wannee Jiraungkoorskul
Feb 2, 2018·Scientia pharmaceutica·Jintawee KicuntodThanyada Rungrotmongkol
Aug 21, 2018·Advances in Pharmacological Sciences·Fazleen Izzany Abu BakarAsmah Rahmat
Jun 23, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Aziiz Mardanarian RosdiantoJutti Levita
Dec 3, 2016·BMC Complementary and Alternative Medicine·Adisak WongkajornsilpKittipong Maneechotesuwan
May 1, 2021·International Journal of Molecular Sciences·Alessio OttavianiAlessandro Desideri
Sep 26, 2020·Current Topics in Medicinal Chemistry·Chen XuBan-Feng Ruan

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Methods Mentioned

BETA
column chromatography

Software Mentioned

SPSS

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