In vitro anti-Trichomonas vaginalis activity of Pistacia lentiscus mastic and Ocimum basilicum essential oil

Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology
Hayam Mohamed Ezz Eldin, Abeer Fathy Badawy

Abstract

Trichomonas vaginalis is a protozoan parasite that causes trichomoniasis; a cosmopolitan sexually transmitted disease. Metronidazole is the drug of choice for T. vaginalis infections. The increase in metronidazole resistant parasites and undesirable side effects of this drug makes the search for an alternative a priority for the management of trichomoniasis. Pistacia lentiscus mastic and Ocimum basilicum oil are known for their antibacterial, antifungal, antiviral and antiprotozoal effects. The present study was carried out to investigate the in vitro effects of P. lentiscus mastic and O. basilicum oil on T. vaginalis trophozoites. The effects of different concentrations of P. lentiscus mastic (15, 10 and 5 mg/ml) and different concentrations of O. basilicum oil (30, 20 and 10 μg/ml) on multiplication of trophozoites at different time points (after 24, 48, 72 and 96 h) were determined, also morphological changes were reported by transmission electron microscopy (TEM). The results showed that both plants caused an inhibition of growth of T. vaginalis trophozoites. The minimal lethal concentration of P. lentiscus mastic was 15 mg/ml after 24 h incubation, 10 mg/ml after 48 h and 5 mg/ml after 96 h. The minimal lethal concentratio...Continue Reading

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Citations

Jul 5, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Simona PiccolellaSeverina Pacifico
Jun 6, 2018·Expert Opinion on Drug Metabolism & Toxicology·Piero SestiliCarmela Fimognari
Jun 30, 2019·Clinical Pharmacology in Drug Development·Zadik HazanLeonard A Levin
Jul 17, 2018·Toxicologic Pathology·Yuval RamotAbraham Nyska
Feb 22, 2021·International Journal for Parasitology. Drugs and Drug Resistance·Nooshin HashemiMarlene Benchimol

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