In vitro antiarrhythmic effect of prior whole body hyperthermia: implication of catalase

Journal of Molecular and Cellular Cardiology
M JoyeuxP Demenge

Abstract

The protective effect of heat stress against mechanical dysfunction and myocardial necrosis after prolonged ischemia is well known. We have investigated whether the protective effect of heat stress extends to reperfusion arrhythmias in the isolated perfused rat heart. Rats were exposed to 20 min of 42 degrees C hyperthermia. Twenty-four h later their hearts were isolated, perfused and subjected to a 5-min period of occlusion of the left coronary artery. The incidence and duration of reperfusion arrhythmias were assessed in the 30-min reperfusion period. Prior heat stress led to a reduction in the incidence (from 100 to 60%, P</=0.05) and duration (from 611+/-251 to 62+/-51 s, P</=0.05) of ventricular tachycardia and/or fibrillation, upon reperfusion following a 5-min ischemic period. This prevention of reperfusion arrhythmias was associated with a two-fold increase in endogenous catalase activity and an enhanced heat stress protein hsp 72 and 27 expression. Catalase inhibition by 3-amino triazole (AT) abolished the antiarrhythmic effect of heat stress. The incidence (80 v 100%) and duration (691+/-238 v 989+/-242 s) of reperfusion arrhythmias were not different between the group heat shocked + AT and the group treated only with...Continue Reading

Citations

Oct 14, 2003·Toxicology and Applied Pharmacology·Delphine WirthPascal Gustin
Feb 23, 1999·Fundamental & Clinical Pharmacology·M JoyeuxC Ribuot
Nov 18, 2006·Circulation Research·Bianca J J M BrundelStanley Nattel
Jan 25, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Chunlian ZhangCam Patterson
Mar 22, 2003·American Journal of Physiology. Heart and Circulatory Physiology·Joseph W StarnesYoonjung Park

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