In vitro antibacterial activity of DU-6859a, a new fluoroquinolone.

Antimicrobial Agents and Chemotherapy
T NakaneS Mitsuhashi

Abstract

The in vitro antibacterial activity of DU-6859a, a new fluoroquinolone, against a wide variety of clinical isolates was evaluated and compared with those of tosufloxacin, ofloxacin, ciprofloxacin, and sparfloxacin. DU-6859a showed potent broad-spectrum activity against gram-positive, gram-negative, and anaerobic bacteria, and its activity was greater than those of the control quinolones. By comparison of MICs at which 90% of strains are inhibited, DU-6859a had potent activity against bacteria resistant to the control quinolones. The time-killing curves of quinolones showed that the number of viable cells decreased rapidly during 2 to 4 of incubation, and regrowth was not seen even after 8 h incubation. At a concentration of four times the MIC, the frequencies of appearance of spontaneous mutants of Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa resistant to DU-6859a were < or = 4.0 x 10(-9) to 1.9 x 10(-8). The 50% inhibitory concentrations of DU-6859a were 0.86 and 1.05 micrograms/ml for the supercoiling activities of DNA gyrases isolated from E. coli and P. aeruginosa, respectively. The rank order of the 50% inhibitory concentrations observed for both DNA gyrases roughly paralleled the MICs.

References

Nov 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M GellertH A Nash
Jul 1, 1992·Antimicrobial Agents and Chemotherapy·K SatoY Osada
Nov 1, 1989·Antimicrobial Agents and Chemotherapy·T KojimaS Mitsuhashi
Jun 1, 1988·Antimicrobial Agents and Chemotherapy·K FujimakiS Mitsuhashi
Nov 1, 1986·Antimicrobial Agents and Chemotherapy·K SatoS Mitsuhashi
Oct 1, 1982·Antimicrobial Agents and Chemotherapy·K SatoS Mitsuhashi

❮ Previous
Next ❯

Citations

Jun 29, 2002·Diagnostic Microbiology and Infectious Disease·Wang-Huei ShengWei-Chuan Hsieh
Aug 25, 1999·Diagnostic Microbiology and Infectious Disease·E J Giamarellou-BourboulisH Giamarellou
Feb 24, 2001·International Journal of Antimicrobial Agents·P C Appelbaum, P A Hunter
Sep 21, 2000·The Journal of Antimicrobial Chemotherapy·P Ball
Oct 16, 2001·Antimicrobial Agents and Chemotherapy·N MiyashitaT Matsushima
Nov 26, 2003·Antimicrobial Agents and Chemotherapy·Frederick A BrownePeter C Appelbaum
Dec 5, 2009·Médecine et maladies infectieuses·V Cattoir, C Daurel
Feb 27, 1999·Antimicrobial Agents and Chemotherapy·T AkasakaK Sato

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.