In vitro antibacterial activity of vertilmicin and its susceptibility to modifications by the recombinant AAC6'-APH2'' enzyme.

Antimicrobial Agents and Chemotherapy
Cong-Ran LiXue-Fu You

Abstract

Vertilmicin is a new semisynthetic aminoglycoside with a structure similar to that of netilmicin except for a methyl group at the C-6' position. In the present study, the in vitro antibacterial activity of vertilmicin was studied, and its susceptibility to modifications by the recombinant aminoglycoside bifunctional modifying enzyme AAC(6')-APH(2'') was compared with those of verdamicin and netilmicin. A total of 1,185 clinical isolates collected from hospitals in Beijing between 2000 and 2001 were subjected to the in vitro antibacterial activity evaluations, including MIC, minimum bactericidal concentration (MBC), and time-kill curve tests. The MICs were evaluated in non-gentamicin-resistant (gentamicin-susceptible and gentamicin-intermediate) strains and gentamicin-resistant strains, respectively. For most of the non-gentamicin-resistant bacteria (except for the isolates of Pseudomonas spp.), the MIC(90)s of vertilmicin were in the range of 0.5 to 8 microg/ml, comparable to those of the reference aminoglycosides. For the gentamicin-resistant isolates, the three semisynthetic aminoglycosides (vertilmicin, netilmicin, and amikacin) demonstrated low MIC(50)s and/or MIC(90)s, as well as high percent susceptibility values. Among t...Continue Reading

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Citations

Apr 19, 2011·European Journal of Drug Metabolism and Pharmacokinetics·Mao-Jin ZhouChang-Xiao Liu
Jul 29, 2009·Antimicrobial Agents and Chemotherapy·Xue-Fu YouJian-Dong Jiang
Mar 23, 2013·Journal of Pharmaceutical and Biomedical Analysis·Yao-zuo YuanErwin Adams
Aug 6, 2014·ACS Nano·Iryna ZhukSvetlana A Sukhishvili
Dec 20, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria S Ramirez, Marcelo E Tolmasky
Jan 10, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Alexey S KovtunValery N Danilenko

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