In vitro antibacterial and antibiotic-potentiation activities of four edible plants against multidrug-resistant gram-negative species

BMC Complementary and Alternative Medicine
Jaurès A K NoumedemVictor Kuete

Abstract

The present study was designed to investigate the antibacterial activities of the methanol extracts of four Cameroonian edible plants, locally used to treat microbial infections, and their synergistic effects with antibiotics against a panel of twenty nine Gram-negative bacteria including Multi-drug resistant (MDR) phenotypes expressing active efflux pumps. The broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) of the extracts [alone and in the presence of the efflux pumps inhibitor (EPI) Phenylalanine-Arginine β-Naphtylamide (PAβN)], and those of antibiotics in association with the two of the most active ones, Piper nigrum and Telfairia occidentalis. The preliminary phytochemical screening of the extracts was conducted according to the standard phytochemical methods. Phytochemical analysis showed the presence of alkaloids and flavonoids in all studied extracts. Other chemical classes of secondary metabolites were selectively present in the extracts. The results of the MIC determination indicated that the crude extracts from P. nigrum and V. amygdalina were able to inhibit the growth of all the twenty nine studied bacteria within a concentration range of 32 to 1024 μg/mL. At a similar ...Continue Reading

References

Sep 1, 1979·Planta medica·H WagnerR Deininger
Aug 1, 1992·International Journal of Food Microbiology·V Moleyar, P Narasimham
Aug 1, 1997·Bioorganic & Medicinal Chemistry·V S ParmarM M Mareel
Oct 9, 1999·Clinical Microbiology Reviews·M M Cowan
Mar 18, 2003·Journal of Ethnopharmacology·I KaramanA Adigüzel
Mar 12, 2004·Journal of Ethnopharmacology·E S Sunila, G Kuttan
Jul 3, 2004·Redox Report : Communications in Free Radical Research·R S VijayakumarN Nalini
Nov 2, 2004·The Journal of Antibiotics·Takeo OnoShigeo Morimoto
Nov 9, 2004·BMC Complementary and Alternative Medicine· TajuddinIqbal Ahmad Qasmi
May 26, 2005·The Journal of Antimicrobial Chemotherapy·Keith Poole
Sep 22, 2005·Canadian Journal of Microbiology·L C BragaA M A Nascimento
Jan 24, 2006·Biochemical Pharmacology·Olga Lomovskaya, Keith A Bostian
Feb 21, 2007·Journal of Natural Products·David J Newman, Gordon M Cragg
Jul 5, 2007·Current Opinion in Infectious Diseases·Stijn BlotDirk De Bacquer
Aug 19, 2007·Journal of Asian Natural Products Research·Song LiMin-Wei Wang
Aug 21, 2007·European Journal of Pharmacology·Neelima Pathak, Shashi Khandelwal
Feb 1, 2007·Pakistan Journal of Biological Sciences : PJBS·Olorunfemi A EseyinEmmanuel Oforah
Mar 5, 2009·Antimicrobial Agents and Chemotherapy·Vannina LorenziJean-Michel Bolla
Mar 13, 2009·PloS One·Jean-Marie PagesMarie-Hélène Nicolas-Chanoine
Apr 30, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gwendoline Cheng Lian EeChoon Fah Joseph Bong
Mar 17, 2011·Annals of Clinical Microbiology and Antimicrobials·Shahedur RahmanMahboob Hossain Khan

Citations

May 12, 2015·Journal of Medicinal Food·Abidemi James AkindeleBlessing Amarachi Usuwah
Feb 13, 2015·Natural Product Research·Lorena DiblasiElena Cartagena
Nov 14, 2014·Chemical Biology & Drug Design·Erin E GillRobert E W Hancock
Jul 15, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Francis OchengAnders Gustafsson
Feb 12, 2019·Critical Reviews in Food Science and Nutrition·Heerasing TakooreeMohamad F Mahomoodally
May 15, 2018·Advances in Pharmacological Sciences·Abere Habtamu, Yadessa Melaku

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