In vitro antibiotic susceptibilities of ocular isolates in North and South America. In Vitro Antibiotic Testing Group

Cornea
H G Jensen, C Felix

Abstract

To assess the in vitro susceptibility of ocular bacterial isolates from North and South America to antiinfectives that are commonly used in the treatment of external ocular infection. Ocular isolates (n = 1,291) from 12 laboratories in the United States, Canada, Mexico, and Argentina were tested for their susceptibility to ofloxacin, ciprofloxacin, norfloxacin, gentamicin, tobramycin, chloramphenicol, tetracycline, and erythromycin using both disk-diffusion and broth-dilution methods. When the results from disk-diffusion and broth-dilution testing were combined, the relative overall in vitro efficacy was (in decreasing order): ofloxacin, ciprofloxacin, norfloxacin, gentamicin, chloramphenicol, tobramycin, tetracycline, and erythromycin. Against gram-positive organisms it was: ofloxacin, ciprofloxacin equivalent to chloramphenicol, norfloxacin, tetracycline, gentamicin, and erythromycin equivalent to tobramycin. Against gram-negative organisms it was: ofloxacin equivalent to ciprofloxacin and norfloxacin, gentamicin, tobramycin, chloramphenicol, and tetracycline comparable to erythromycin. The fluoroquinolones ofloxacin, ciprofloxacin, and norfloxacin had higher overall in vitro efficacy than the other antibiotics tested. Of the...Continue Reading

Citations

Dec 19, 2015·Ocular Immunology and Inflammation·Ama SadakaMichael S Gilmore
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Jan 26, 2007·Cornea·Adália Dias Dourado OliveiraWaldemar Francisco
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