In vitro anticancer potential of BaCO3 nanoparticles synthesized via green route

Journal of Photochemistry and Photobiology. B, Biology
Patnamsetty Chidanandha NagajyothiJaesool Shim

Abstract

Green synthesis of nanoparticles is a growing research area because of their potential applications in nanomedicine. Barium carbonate nanoparticles (BaCO3 NPs) were synthesized using an aqueous extract of Mangifera indica seed as a reducing agent. These particles were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), Transmission electron microscopy (TEM), selected area electron diffraction (SAED), Energy-dispersive-X-ray (EDX) and X-ray photoelectron spectroscopy (XPS) analysis. HR-TEM images are confirmed that green synthesized BaCO3 NPs have spherical, triangular and uneven shapes. EDX analysis confirmed the presence of Ba, C and O. The peaks at 2θ of 19.45, 23.90, 24.29, 27.72, 33.71, 34.08, 34.60, 41.98, 42.95, 44.18, 44.85, and 46.78 corresponding to (110), (111), (021), (002), (200), (112), (130), (221), (041), (202), (132) and (113) showed that BaCO3 NPs average size was ~18.3 nm. SAED pattern confirmed that BaCO3 NPs are crystalline nature. BaCO3 NPs significantly inhibited cervical carcinoma cells, as evidenced by cytotoxicity assay. Immunofluorescence and fluorescence assays showed that BaCO3 NPs increased the expression and activity of caspase-3, an autocatalytic enzyme that ...Continue Reading

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Citations

Oct 25, 2016·Chemical Society Reviews·Chunhua CaiLiquan Wang
May 19, 2017·Amino Acids·Muthuraman PanduranganDoo Hwan Kim
Jun 9, 2020·Critical Reviews in Food Science and Nutrition·Bilal MirzaAnupam Bishayee
Jun 25, 2020·International Journal of Molecular Sciences·Edouard Alphandéry
May 3, 2021·Bioprocess and Biosystems Engineering·Nooshin HashemiMehrdad Khatami
Jun 27, 2020·International Journal of Pharmaceutics·Edouard Alphandéry

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