In vitro antifungal activity of hydroxychavicol isolated from Piper betle L.

Annals of Clinical Microbiology and Antimicrobials
Intzar AliInshad A Khan

Abstract

Hydroxychavicol, isolated from the chloroform extraction of the aqueous leaf extract of Piper betle L., (Piperaceae) was investigated for its antifungal activity against 124 strains of selected fungi. The leaves of this plant have been long in use tropical countries for the preparation of traditional herbal remedies. The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of hydroxychavicol were determined by using broth microdilution method following CLSI guidelines. Time kill curve studies, post-antifungal effects and mutation prevention concentrations were determined against Candida species and Aspergillus species "respectively". Hydroxychavicol was also tested for its potential to inhibit and reduce the formation of Candida albicans biofilms. The membrane permeability was measured by the uptake of propidium iodide. Hydroxychavicol exhibited inhibitory effect on fungal species of clinical significance, with the MICs ranging from 15.62 to 500 microg/ml for yeasts, 125 to 500 microg/ml for Aspergillus species, and 7.81 to 62.5 microg/ml for dermatophytes where as the MFCs were found to be similar or two fold greater than the MICs. There was concentration-dependent killing of Candida albicans and C...Continue Reading

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Citations

Jul 9, 2013·European Journal of Medicinal Chemistry·Ma Ángeles CastroArturo San Feliciano
Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·Ahmed MoussaBenhalima Abdelkader
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Methods Mentioned

BETA
fluorescence-activated cell sorting

Software Mentioned

Cell Quest Pro

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