Abstract
The in vitro activity of luliconazole (NND-502), a novel imidazole antifungal agent, against dermatophytes and several other groups of medically important fungi including the rare causative agents of dermatomycoses, was studied. The luliconazole susceptibility tests were performed with a total of 58 fungal strains of 23 species of fungi grouped into dermatophytes, dematiaceous fungi, hyaline hyphomycetes, yeastlike fungi, and zygomycetes using a broth microdilution method with RPMI 1640 medium. The minimum inhibitory concentration (MIC) values for luliconazole were compared with those of three reference drugs, lanoconazole (LCZ), bifonazole (BFZ), and terbinafine (TBF), all of which have been popular for the topical treatment of dermatophytosis, cutaneous candidiasis, and other superficial fungal infections in Japan. Luliconazole inhibited growth of all filamentous fungi except zygomycetes at low concentrations (MIC, < or =0.004-0.125 microg/ml), with dermatophytes being most susceptible (MIC, < or =0.004-0.008 microg/ml). The susceptibility of these filamentous fungi to luliconazole was almost equal to that to LCZ, and surpassed TBF and BFZ, although to a lesser extent; yeastlike fungi were also susceptible to luliconazole (MI...Continue Reading
Citations
Oct 26, 2012·Current Microbiology·Florin Aonofriesei, Simona Lupsor
Dec 31, 2008·Medical Mycology·Hiroyasu KogaRyoji Tsuboi
Apr 3, 2013·Antimicrobial Agents and Chemotherapy·T Jones, A Tavakkol
Mar 7, 2012·Antimicrobial Agents and Chemotherapy·Hiroyasu KogaRyoji Tsuboi
Jan 30, 2014·Anais Brasileiros De Dermatologia·Maria Fernanda Reis Gavazzoni DiasDavid Rubem Azulay
Nov 30, 2011·Medical Mycology Journal·Shigeharu InouyeShigeru Abe
Apr 3, 2012·Medical Mycology Journal·Shigeharu InouyeShigeru Abe
Nov 13, 2015·Expert Review of Anti-infective Therapy·Michael H Gold, Jason T Olin
Apr 27, 2012·Expert Opinion on Pharmacotherapy·Aditya K Gupta, Fiona C Simpson
Sep 28, 2013·Expert Opinion on Investigational Drugs·Aditya K Gupta, Fiona C Simpson
Dec 8, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mustafa M A Elsayed
Mar 5, 2016·Medical Mycology Journal·Tsuyoshi ShimamuraNobuo Kubota
Mar 5, 2016·Medical Mycology Journal·Tsuyoshi ShimamuraNobuo Kubota
Mar 14, 2014·Mycoses·Richard K ScherAmir Tavakkol
Sep 1, 2015·Medical Mycology·Keiko Wakumoto-NakashimaOsamu Yamamoto
Jul 11, 2006·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Hiroyasu KogaHideyo Yamaguchi
Dec 3, 2016·Medical Mycology Journal·Tsuyoshi ShimamuraKazutoshi Shibuya
Mar 24, 2017·The Journal of Dermatology·Shinichi WatanabeAkihiro Okubo
Aug 30, 2017·Antimicrobial Agents and Chemotherapy·Gholam Reza ShokoohiKoichi Makimura
Apr 9, 2014·Antimicrobial Agents and Chemotherapy·Nathan P WiederholdAmir Tavakkol
Aug 31, 2016·Antimicrobial Agents and Chemotherapy·Mahdi AbastabarHamid Badali
Nov 7, 2006·Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology·Hiroyasu KogaRyoji Tsuboi
Aug 14, 2019·Mycoses·Mahdi AbastabarHamid Badali
Oct 22, 2019·Journal of Liposome Research·Manjot KaurSubheet Kumar Jain
Sep 17, 2015·Current Opinion in Infectious Diseases·Nathan P Wiederhold, Thomas F Patterson
Jul 5, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kenichi Kishii
Feb 10, 2019·Scientific Reports·Xia DaEishin Morita
May 22, 2019·Medical Mycology·Tomoyuki IwanagaTakashi Mochizuki
Oct 7, 2018·Mycopathologia·Shigehiro HagiwaraKoichi Makimura
Feb 27, 2020·3 Biotech·Vivek DaveKajal Tak
Nov 14, 2018·Cornea·Daisuke TodokoroHideo Akiyama
Nov 2, 2020·Molecular Biology Reports·Maral GharaghaniAli Zarei Mahmoudabadi
Apr 26, 2021·Drug Delivery and Translational Research·Arisha MahmoodGautam Singhvi
Aug 3, 2021·Frontiers in Cellular and Infection Microbiology·Samaneh HalvaeeHasti Kamali Sarvestani
Aug 6, 2021·Journal of Basic Microbiology·Saraswathi NagarajShoba Narayan