In vitro antifungal activity of ravuconazole against isolates of dermatophytes and Candida species from patients with dermatomycoses

Medical Mycology Journal
Hideyo YamaguchiTakashi Mikawa

Abstract

The in vitro activity of ravuconazole (RVCZ) was compared with those of itraconazole (ITCZ) and terbinafine (TBF) against 73 dermatophyte isolates and 18 Candida spp. isolates recovered from patients with dermatomycosis at 4 dermatological clinics in Japan in 2011. The dermatophyte isolates consisted of Trichophyton rubrum (n=51), Trichophyton mentagrophytes (n=20 : these strains were not identified by molecular phylogenetic analysis.), Trichophyton tonsurans (n=1), and Microsporum canis (n=1). The Candida spp. isolates comprised C. albicans (n=11), C. parapsilosis (n=5), C. guilliermondii (n=1), and C. pseudohaemulonii (n=1). RVCZ was highly active against all dermatophytes and all Candida spp. : the geometric mean (GM) MICs for T. rubrum and T. mentagrophytes were 0.035 μg/mL and MICs for T. tonsurans and M. canis were ≤ 0.03 μg/mL, and GM MICs for C. albicans and C. parapsilosis were ≤ 0.03 μg/mL and MICs for C. guilliermondii and C. pseudohaemulonii were 0.25 and ≤ 0.03 μg/mL, respectively. Compared to RVCZ, ITCZ showed similar anti-dermatophytic and anti-Candida activities, while TBF had a slightly higher anti-dermatophytic but a markedly lower anti-Candida activity. These results suggest that RVCZ is a potential candidate...Continue Reading

References

Aug 28, 1999·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·B S Schlefman
Dec 1, 1999·Diagnostic Microbiology and Infectious Disease·J C Fung-TomcD P Bonner
Nov 13, 2001·American Journal of Clinical Dermatology·B E Elewski
Mar 20, 2004·The British Journal of Dermatology·A K GuptaA M Johnson
Apr 21, 2004·Journal of the American Academy of Dermatology·K Wade FosterBoni E Elewski
Feb 1, 2005·Mycoses·Clara RomanoElisa M Difonzo
Jul 1, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·A K GuptaUNKNOWN Ravuconazole onychomycosis group
Feb 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mi-Na KimDong Wook Ryang
May 9, 2009·Mycopathologia·Patricio Godoy-MartinezOlga Fischman
Dec 7, 2010·Medical Mycology·Iara Trocoli Drakensjö, Erja Chryssanthou
May 1, 2012·Mycoses·Chander Grover, Ananta Khurana

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