Abstract
The in vitro activity of ravuconazole (RVCZ) was compared with those of itraconazole (ITCZ) and terbinafine (TBF) against 73 dermatophyte isolates and 18 Candida spp. isolates recovered from patients with dermatomycosis at 4 dermatological clinics in Japan in 2011. The dermatophyte isolates consisted of Trichophyton rubrum (n=51), Trichophyton mentagrophytes (n=20 : these strains were not identified by molecular phylogenetic analysis.), Trichophyton tonsurans (n=1), and Microsporum canis (n=1). The Candida spp. isolates comprised C. albicans (n=11), C. parapsilosis (n=5), C. guilliermondii (n=1), and C. pseudohaemulonii (n=1). RVCZ was highly active against all dermatophytes and all Candida spp. : the geometric mean (GM) MICs for T. rubrum and T. mentagrophytes were 0.035 μg/mL and MICs for T. tonsurans and M. canis were ≤ 0.03 μg/mL, and GM MICs for C. albicans and C. parapsilosis were ≤ 0.03 μg/mL and MICs for C. guilliermondii and C. pseudohaemulonii were 0.25 and ≤ 0.03 μg/mL, respectively. Compared to RVCZ, ITCZ showed similar anti-dermatophytic and anti-Candida activities, while TBF had a slightly higher anti-dermatophytic but a markedly lower anti-Candida activity. These results suggest that RVCZ is a potential candidate...Continue Reading
References
Oct 1, 1996·Antimicrobial Agents and Chemotherapy·K HataK Katsu
Dec 3, 1998·Antimicrobial Agents and Chemotherapy·M A PfallerR A Hajjeh
Aug 28, 1999·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·B S Schlefman
Sep 3, 1999·Antimicrobial Agents and Chemotherapy·D J DiekemaR N Jones
Dec 1, 1999·Diagnostic Microbiology and Infectious Disease·J C Fung-TomcD P Bonner
Jan 20, 2000·Antimicrobial Agents and Chemotherapy·C B MooreD W Denning
Sep 27, 2000·Journal of the American Academy of Dermatology·M A GhannoumB Elewski
Aug 30, 2001·Journal of Clinical Microbiology·M A PfallerUNKNOWN SENTRY Participant Group
Nov 13, 2001·American Journal of Clinical Dermatology·B E Elewski
May 23, 2002·Antimicrobial Agents and Chemotherapy·M A PfallerD J Diekema
Mar 20, 2004·The British Journal of Dermatology·A K GuptaA M Johnson
Apr 14, 2004·Mycoses·E L Svejgaard, J Nilsson
Apr 21, 2004·Journal of the American Academy of Dermatology·K Wade FosterBoni E Elewski
Feb 1, 2005·Mycoses·Clara RomanoElisa M Difonzo
Apr 19, 2005·Medical Mycology·A K GuptaR Batra
Jul 1, 2005·Journal of the European Academy of Dermatology and Venereology : JEADV·A K GuptaUNKNOWN Ravuconazole onychomycosis group
Jun 21, 2006·Microbiology and Immunology·Takashi SugitaNanthawan Mekha
Feb 6, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Mi-Na KimDong Wook Ryang
May 9, 2009·Mycopathologia·Patricio Godoy-MartinezOlga Fischman
Dec 7, 2010·Medical Mycology·Iara Trocoli Drakensjö, Erja Chryssanthou
May 1, 2012·Mycoses·Chander Grover, Ananta Khurana
Citations
Jul 30, 2019·The Journal of Dermatology·Hiromitsu NoguchiHironobu Ihn
Dec 26, 2019·Japanese Journal of Infectious Diseases·Rui KanoMasataro Hiruma
Aug 30, 2018·The Journal of Dermatology·Shinichi WatanabeAkihiro Okubo
May 17, 2018·Clinical and Translational Science·Yasuyuki IshiiNaoto Uemura
Dec 3, 2016·Medical Mycology Journal·Hideyo Yamaguchi