In vitro antimicrobial activity of hydroxy and N4-acetyl sulphonamide metabolites

The Veterinary Quarterly
J F NouwsY A Hekster

Abstract

Hydroxylated metabolites of sulphadimidine, sulphamerazine, sulphatroxazole, sulphamethoxazole, and sulphadiazine exhibited antimicrobial activity against Escherichia coli 28 PR 271 test strain ranging from 2.5 to 39.5 per cent of that of the parent drug. Trimethoprim addition potentiated the antimicrobial activity of these metabolites. N4-acetyl sulphonamide metabolites possessed no antimicrobial activity, nor did trimethoprim potentiated them.

References

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Citations

Jul 10, 2007·Analytical and Bioanalytical Chemistry·Marc LamshöftMichael Spiteller
Jul 3, 2013·Environmental Science and Pollution Research International·Hongyou JiangXian Zhang
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Related Concepts

Acetylation
Metazoa
Thin Layer Chromatography
Alkalescens-Dispar Group
Hydroxylation
Sulfonamides

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