Abstract
In this prospective multicentric study, we assessed the in vitro antimicrobial activity of carbapenems (imipenem, meropenem, and doripenem), tigecycline, and colistin against 166 unusual nonfermenting Gram-negative bacilli (NF-GNB) clinical isolates collected from nine French hospitals during a 6-month period (from December 1, 2008, to May 31, 2009). All NF-GNB isolates were included, except those phenotypically identified as Pseudomonas aeruginosa or Acinetobacter baumannii. Minimal inhibitory concentrations (MICs) of antimicrobial agents were determined by using the E-test technique. The following microorganisms were identified: Stenotrophomonas maltophilia (n=72), Pseudomonas spp. (n=30), Achromobacter xylosoxidans (n=25), Acinetobacter spp. (n=18), Burkholderia cepacia complex (n=9), Alcaligenes faecalis (n=7), and Delftia spp. (n=5). All isolates of Acinetobacter spp., A. faecalis, and Delftia spp. were susceptible to the three carbapenems. Imipenem exhibited the lowest MICs against Pseudomonas spp., and meropenem, as compared with imipenem and doripenem, displayed an interesting antimicrobial activity against A. xylosoxidans and B. cepacia complex isolates. Conversely, no carbapenem exhibited any activity against S. malto...Continue Reading
References
Jan 4, 2001·Journal of Clinical Microbiology·A C GalesR N Jones
Dec 25, 2002·Antimicrobial Agents and Chemotherapy·D MilatovicA C Fluit
Feb 20, 2004·The Journal of Antimicrobial Chemotherapy·A C NicodemoA C Gales
Jan 25, 2005·International Journal of Antimicrobial Agents·Helio S Sader, Ronald N Jones
Jun 28, 2005·Drugs·Ethan Rubinstein, David Vaughan
Aug 18, 2005·Diagnostic Microbiology and Infectious Disease·Daryl J HobanUNKNOWN Tigecycline Evaluation and Surveillance Trial (TEST Program) Group
Nov 23, 2005·Memórias do Instituto Oswaldo Cruz·Ana C GalesHelio S Sader
Dec 20, 2005·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Nai-Cheng ChengCheng-Yi Liu
Aug 26, 2006·The Lancet Infectious Diseases·Jian LiDavid L Paterson
May 10, 2007·Drugs·George G ZhanelJames A Karlowsky
Aug 3, 2007·International Journal of Antimicrobial Agents·D A EnochH A Ludlam
Jun 3, 2008·Diagnostic Microbiology and Infectious Disease·George G ZhanelUNKNOWN Canadian Antimicrobial Resistance Alliance
Dec 17, 2008·Diagnostic Microbiology and Infectious Disease·Philip J Turner
Mar 3, 2009·Diagnostic Microbiology and Infectious Disease·Mariana CastanheiraDavid M Livermore
Apr 28, 2009·Diagnostic Microbiology and Infectious Disease·Marc H ScheetzChao Qi
Nov 6, 2009·International Journal of Antimicrobial Agents·Marisa AlmuzaraCarlos Vay
Jan 6, 2010·International Journal of Antimicrobial Agents·Hui WangXinhong Huang
Mar 20, 2010·BMC Infectious Diseases·Marie-Laure Joly-GuillouMicheline Roussel-Delvallez
Apr 7, 2010·Antimicrobial Agents and Chemotherapy·David J FarrellRonald N Jones
Aug 24, 2010·Diagnostic Microbiology and Infectious Disease·Yun F Wayne Wang, Michael J Dowzicky
Aug 24, 2010·Diagnostic Microbiology and Infectious Disease·Thean Yen TanDorene Mei Mei Chen
Oct 19, 2010·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Harim LeeKyong Ran Peck
Oct 20, 2010·Diagnostic Microbiology and Infectious Disease·Rodrigo E MendesRonald N Jones
Mar 1, 2011·Diagnostic Microbiology and Infectious Disease·George G ZhanelUNKNOWN Canadian Antimicrobial Resistance Alliance (CARA)
Mar 9, 2011·The Journal of Infection·Yen-Hsu ChenDavid L Paterson
Apr 22, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·H JacquierV Cattoir
May 25, 2011·Antimicrobial Agents and Chemotherapy·Marisa N AlmuzaraCarlos A Vay
Jun 21, 2011·The Journal of Antimicrobial Chemotherapy·Dafna YahavLeonard Leibovici
Jul 1, 2011·The Journal of Antimicrobial Chemotherapy·Ana C GalesHélio S Sader
Jan 17, 2012·The Journal of Infection·Vincent FihmanJean-Ralph Zahar
Citations
Sep 11, 2012·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P D CroughsUNKNOWN Antibiotic Resistance Surveillance Group
Jun 19, 2013·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Abbas BahadorReza Raoofian
Jul 6, 2014·Indian Journal of Plastic Surgery : Official Publication of the Association of Plastic Surgeons of India·Zhi Yang NgKah Woon Leo
May 30, 2014·Indian Journal of Pediatrics·Saikat PatraSwathi Mishra
Sep 5, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Lucie AmoureuxCatherine Neuwirth
Oct 4, 2014·Clinical Microbiology Reviews·Axel Dalhoff
Jun 18, 2015·PloS One·Qianqian LiuYi Xie
Sep 4, 2015·Annals of Saudi Medicine·Deniz TugcuNezahat Gurler
Sep 1, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Raphaël E DuvalBéatrice Demoré
Aug 21, 2020·Antimicrobial Agents and Chemotherapy·Burcu IslerDavid L Paterson