In vitro antimicrobial and anti-proliferative activities of plant extracts from Spathodea campanulata, Ficus bubu, and Carica papaya

Pharmaceutical Biology
Jean Emmanuel Mbosso TeinkelaRené Wintjens

Abstract

African medicinal plants represent a prominent source of new active substances. In this context, three plants were selected for biological investigations based on their traditional uses. The antimicrobial and anti-proliferative features of three plants used for medicinal purpose were evaluated. The antimicrobial activities of methanol extracts of Ficus bubu Warb. (Moraceae) stem bark and leaves, of Spathodea campanulata P. Beauv. (Bignoniaceae) flowers, as well as those of Carica papaya Linn. (Caricaceae) latex, were determined using the microbroth dilution method against a set of bacteria and fungi pathogens including: Enterococcus faecalis, Staphylococcus aureus, S. saprophyticus, S. epidermididis, Escherichia coli, Klebsiella pneumonia, Salmonella typhimurium, Candida albicans, and Trichophyton rubrum. The tested concentrations of extracts ranged from 2500.0 to 2.4 μg/mL and MIC values were evaluated after 24 h incubation at 37 °C. Subsequently, MTT assay was used to estimate anti-proliferative activity of these methanol extracts and of F. bubu latex on three human cancer cell lines (U373 glioblastoma, A549 NSCLC, and SKMEL-28 melanoma). The methanol extract of F. bubu stem bark exhibited the highest antimicrobial activity a...Continue Reading

References

Jan 1, 1986·Memórias do Instituto Oswaldo Cruz·N M MendesN Katz
Jan 1, 1995·Methods in Enzymology·R Wynn, F M Richards
May 6, 1999·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·G NiyonzimaA J Vlietinck
Apr 11, 2000·The Journal of Pharmacy and Pharmacology·R Verpoorte
Mar 17, 2001·Environmental Health Perspectives·D S Fabricant, N R Farnsworth
Apr 12, 2001·Journal of Ethnopharmacology·B SripanidkulchaiD Jirakulsomchok
Nov 6, 2001·The American Journal of Tropical Medicine and Hygiene·G P Bhat, N Surolia
Mar 15, 2003·Nature Reviews. Cancer·John Mann
Mar 5, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·G A Pankey, L D Sabath
Sep 30, 2004·Bulletin of Experimental Biology and Medicine·E V Mikhal'chikL G Korkina
Feb 25, 2005·Nature Reviews. Drug Discovery·Frank E Koehn, Guy T Carter
Jul 26, 2005·Journal of Ethnopharmacology·P J HoughtonA M Deters
Oct 17, 2006·Journal of Ethnobiology and Ethnomedicine·Cheryl A Lans
Feb 21, 2007·Journal of Natural Products·David J Newman, Gordon M Cragg
Mar 29, 2007·Natural Product Reports·Karl-Heinz Altmann, Jürg Gertsch
May 3, 2007·International Journal of Dermatology·Shahab BohlooliSedigheh Pashapoor
Jul 14, 2007·Journal of Ethnopharmacology·Fernando CalzadaAmparo Tapia-Contreras
Nov 6, 2007·American Journal of Infection Control·Robert C MoelleringUNKNOWN American Society for Microbiology
Mar 7, 2008·Natural Product Research·Emmanuel Jean Teinkela MbossoEtienne Tsamo
May 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Rachel J Gordon, Franklin D Lowy
Jul 1, 2008·Journal of Ethnopharmacology·Anwarul Hassan GilaniSheikh Arshad Saeed
Sep 2, 2008·Inflammopharmacology·Bamidele V OwoyeleAyodele O Soladoye
Dec 2, 2008·Journal of Ethnopharmacology·Shila Gurung, Natasa Skalko-Basnet
Mar 6, 2009·Micron : the International Research and Review Journal for Microscopy·S SangethaS Sasidharan
Jul 11, 2009·Science·Jesse W-H Li, John C Vederas
Dec 8, 2009·Journal of Ethnopharmacology·Noriko OtsukiChikao Morimoto
Jun 18, 2010·Journal of Medicinal Food·Emmanuel E IlodigweChukwuemeka S Nworu
Jul 21, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gwendoline Van GoietsenovenVéronique Mathieu
Nov 26, 2010·Journal of Ethnopharmacology·Suriyati MohamadSiti Suraiya Md Noor
Feb 5, 2011·Natural Product Research·Houda Lazreg ArefKhaled Said
Jan 28, 2012·Indian Journal of Microbiology·Pedro Chávez-QuintalSantiago Gallegos-Tintoré
Feb 22, 2012·Anti-cancer Agents in Medicinal Chemistry·Giulio MenichiniFilomena Conforti
Mar 13, 2012·Annual Review of Plant Biology·Axel Mithöfer, Wilhelm Boland
Jan 1, 2011·African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM·Kwabena Ofori-KwakyeMarcel Tunkumgnen Bayor
Jun 19, 2012·Journal of Ayurveda and Integrative Medicine·Yasmeen Maniyar, Prabhu Bhixavatimath
Nov 28, 2012·Journal of Ethnopharmacology·Reika Abe, Kazuhiro Ohtani

❮ Previous
Next ❯

Citations

Oct 11, 2017·Pharmacognosy Reviews·Sameh SolimanAyman M Noreddin
Apr 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chun WuGuang-Xiong Zhou
May 19, 2018·Oncotarget·Raghupathy VengojiNicole A Shonka
Oct 11, 2019·Mitochondrial DNA. Part B, Resources·Yi WangJinfeng Zhang
Jul 30, 2021·PloS One·Nelson E MasotaUlrike Holzgrabe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

European Review for Medical and Pharmacological Sciences
R Shilpakala SainathR Malathi
African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM
K Ofori-KwakyeF Adu
Iranian Journal of Pharmaceutical Research : IJPR
Mahboubeh IraniHossein Shaker Bazarnov
© 2022 Meta ULC. All rights reserved