In vitro antimicrobial effect against Streptococcus pneumoniae of adding rifampin to penicillin, ceftriaxone, or 1-ofloxacin.

Antimicrobial Agents and Chemotherapy
K P GironR A Tharappel

Abstract

Adding rifampin to penicillin or l-ofloxacin diminished the rate at which these antibiotics killed 21 clinical isolates isolates of Streptococcus pneumoniae in vitro. A less pronounced inhibitory effect was observed when rifampin was added to ceftriaxone. Synergy was not observed for any bacterial isolate. The in vitro demonstration of indifference or antagonism using these antibiotic combinations argues against the empirical addition of rifampin to beta-lactams or fluoroquinolones in treating serious pneumococcal infections.

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Citations

Feb 18, 2009·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·E ForceF Gudiol
Dec 6, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Amar Safdar
Mar 15, 2006·The Journal of Antimicrobial Chemotherapy·Stephanie K Henderson-BeggLucinda M C Hall

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