In vitro antimicrobial effect and in vivo preventive and therapeutic effects of partially purified lantibiotic lacticin NK34 against infection by Staphylococcus species isolated from bovine mastitis

Journal of Dairy Science
S Y KimY H Park

Abstract

Lantibiotics are small (<5 kDa), polycyclic peptides produced by gram-positive bacteria; they are also known as gram-positive bacteriocins. The high antimicrobial activity of lacticins and the continuing appearance of antibiotic-resistant bacteria in recent years have resulted in a renewed interest in lantibiotics. A partially purified form of lacticin NK34 (a Lactococcus lactis product isolated from the Korean fermented fish jeotgal) was tested to determine its antimicrobial effects against Staphylococcus aureus (n=20) and coagulase-negative Staphylococcus (CNS, n=20) strains isolated from the raw milk of cows with subclinical bovine mastitis in the present study. The spot-on-lawn assay was used to identify the 2 strains from each group with the greatest lacticin NK34 susceptibility, and the minimal lethal dose (MLD) was measured in ICR (imprinting control region) mice. The preventive and therapeutic effects of lacticin NK34 on the mouse infection model were determined for the first time. Lacticin NK34 demonstrated antimicrobial effects in 14 of 20 (70%) S. aureus indicator strains and in 18 of 20 (90%) CNS strains. Staphylococcus aureus 69 and S. simulans 55 demonstrated the greatest susceptibility to lacticin NK34 in the spo...Continue Reading

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Citations

Dec 22, 2011·International Journal of Microbiology·Christopher T Lohans, John C Vederas
Aug 27, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Vincent Peton, Yves Le Loir
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Oct 25, 2016·International Journal of Antimicrobial Agents·Varish AhmadMughees Uddin Siddiqui
Jan 10, 2018·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jovanka LukicIrena Pastar
Dec 3, 2017·Expert Opinion on Drug Discovery·Mengxin Geng, Leif Smith
Sep 3, 2020·FEMS Microbiology Reviews·Samira SoltaniIsmail Fliss
Apr 21, 2017·Emerging Topics in Life Sciences·Kevin EganColin Hill
May 1, 2021·Animals : an Open Access Journal From MDPI·Juan Carlos Hernández-GonzálezNayeli Shantal Castrejón-Jiménez

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