In vitro antimicrobial effect of bacteriocin PsVP-10 in combination with chlorhexidine and triclosan against Streptococcus mutans and Streptococcus sobrinus strains

Archives of Oral Biology
O LobosC Padilla

Abstract

To determine the minimal inhibitory concentrations (MICs) of bacteriocin PsVP-10, chlorhexidine and triclosan on S. mutans and S. sobrinus and to study the potential synergistic combination between these antimicrobial and the bacteriocin PsVP-10. Were determined MICs of bacteriocin PsVP-10, triclosan and chlorhexidine on strains of S. mutans and S. sobrinus, which formed a biofilm or did not form a biofilm. In addition, the synergistic effect was analysed by the determination of respective fractionary inhibitory concentrations (FICs) between bacteriocin PsVP-10 plus chlorhexidine and bacteriocin PsVP-10 plus triclosan. MICs of three antimicrobials used were higher in those bacterial strains, which formed a biofilm. An interesting synergistic effect on both studied species was observed when bacteriocin and chlorhexidine were combined. A slighter synergy was determined for the combination bacteriocin PsVP-10 and triclosan. The results showed that the combination of chlorhexidine bacteriocin PsVP-10 could reduce the number of cariogenic bacteria for in vitro studies. In the future this synergistic combination could be an alternative to antimicrobial therapy against S. mutans or S. sobrinus.

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Citations

Oct 22, 2011·International Journal of Molecular Sciences·Seong-Cheol ParkKyung-Soo Hahm
Sep 6, 2015·International Journal of Antimicrobial Agents·Veronica L CaveraMichael L Chikindas
Jan 24, 2012·Food Microbiology·Natacha Caballero GómezAntonio Gálvez
Jul 15, 2017·Frontiers in Microbiology·Harsh MathurR Paul Ross
Feb 11, 2019·Biotechnology Letters·Gobinath ChandrakasanNorberto Chavarría-Hernández
Apr 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Charles G StarrWilliam C Wimley
Jan 1, 2010·The Journal of Clinical Pediatric Dentistry·Juan Francisco Hernández-SierraAmaury J Pozos-Guillén
Jan 9, 2021·Archives of Oral Biology·John Yun NiuChun Hung Chu

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