Abstract
In a series of bench and clinical trials, our group has determined the immunologic effects and clinical efficacy of a concoction of five herbal ingredients (PentaHerbs Formula, PHF) in treating children with atopic eczema (AE). This study investigates the antimicrobial effects that may be induced with PHF treatment. We investigated the effects of PHF on the minimal inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Staphylococcus aureus and various bacteria that are commonly present on the skin of patients with AE. Staphylococcus aureus ATCC 25923, Methicllin resistant Staphylococcus aureus (MRSA) ATCC BAA-43, Enterococcus faecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853, Escherichia coli ATCC 25922, Enterobacter cloacae ATCC 13047, Proteus vulgaris ATCC 6380, and Acinetobacter baumannii ATCC 19606 were tested. PHF was more effective against Staphylococcus aureus ATCC 25923 and Methicllin resistant Staphylococcus aureus (MRSA) ATCC BAA-43. MIC and MBC were 1 and 25 mg/mL, respectively. PHF was more effective against Staphylococcus aureus ATCC 25923 and Methicllin resistant Staphylococcus aureus (MRSA) ATCC BAA-43t. PHF may be developed into a Staphylococcus aureus targeting topical application.
References
Dec 1, 1991·The Journal of Experimental Medicine·A WalzR M Strieter
Jan 18, 2003·Lancet·Donald Y M Leung, Thomas Bieber
Jan 28, 2005·The American Journal of Chinese Medicine·Kam-Lun Ellis HonPing-Chung Leung
Aug 13, 2005·The Journal of Dermatological Treatment·Kam-Lun Ellis HonTai-Fai Fok
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Bernhard HomeyDonald Y M Leung
Jul 4, 2006·The Journal of Allergy and Clinical Immunology·Laura Y McGirt, Lisa A Beck
May 16, 2007·The British Journal of Dermatology·K L E HonP C Leung
Oct 9, 2007·Advances in Pediatrics·Alexander K C LeungWm Lane M Robson
Mar 18, 2008·The British Journal of Dermatology·T F LeungK L E Hon
Feb 19, 2009·Antimicrobial Agents and Chemotherapy·Hirofumi ShibataTomihiko Higuti
Apr 30, 2011·Chinese Medicine·Kam Lun HonPing Chung Leung
Sep 18, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ben Chung Lap ChanPing Chung Leung
Nov 25, 2016·Journal of Clinical Microbiology·April M BobenchikRomney M Humphries
Feb 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kam Lun HonChun Kwok Wong