PMID: 8457323Jan 1, 1993Paper

In vitro antimicrobial susceptibility testing of rapidly growing mycobacteria using the tablet diffusion method: resistance pattern of Norwegian Mycobacterium fortuitum and Mycobacterium chelonae isolates

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
T HoelJ Eng

Abstract

Thirty-one Norwegian clinical isolates of rapidly growing mycobacteria classified as Runyon's group IV, including 20 Mycobacterium fortuitum and 11 Mycobacterium chelonae strains, were found resistant to a majority of tuberculostatic agents. Minimal inhibitory concentration (MIC) was determined for twelve other antimicrobial agents: amikacin, tobramycin, streptomycin, cefoxitin, imipenem, norfloxacin, ciprofloxacin, doxycycline, erythromycin, fusidic acid, co-trimoxazole and capreomycin. The agar plate dilution method was employed and compared with the agar tablet diffusion method. Regression lines were established correlating MIC values and inhibition zones. The agar tablet diffusion method was found to be a simple and useful method for testing antimicrobial susceptibilities of M. fortuitum and M. chelonae, and a good correlation between MIC values and zone sizes with twelve antimicrobial agents was revealed. Correlation coefficients for most of these antimicrobial agents were around -0.90. M. chelonae was generally more resistant than M. fortuitum. Four antimicrobial agents, capreomycin, norfloxacin, ciprofloxacin and amikacin, showed differences between M. fortuitum and M. chelonae large enough to allow the zone diameter to ...Continue Reading

References

Nov 1, 1991·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·T Hoel, J Eng
Nov 1, 1989·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·E JantzenJ Eng
Feb 1, 1974·Journal of Medical Microbiology·S R PattynJ M Grange
Dec 1, 1970·Annals of Internal Medicine·W L Hand, J P Sanford
Feb 1, 1971·The Journal of Infectious Diseases·A Molavi, L Weinstein
Jul 1, 1983·Reviews of Infectious Diseases·R J WallaceM S Stone
Apr 1, 1982·Journal of General Microbiology·D E MinnikinJ L Stanford

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Citations

Feb 6, 2007·American Journal of Respiratory and Critical Care Medicine·David E GriffithUNKNOWN Infectious Disease Society of America
May 21, 2009·International Journal of Pharmaceutics·Luana PerioliCarlo Rossi
Apr 4, 2019·Southern Medical Journal·Jack ZakrzewskiAnkit I Mehta
Sep 16, 2011·The Journal of Antimicrobial Chemotherapy·Rashmi TandonMridula Bose

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