In vitro antimycobacterial activity of 5-chloropyrazinamide.

Antimicrobial Agents and Chemotherapy
M H CynamonJ T Welch

Abstract

5-Chloropyrazinamide and 5-chloropyrazinoic acid were evaluated for in vitro activity against Mycobacterium tuberculosis, Mycobacterium bovis, and several nontuberculous mycobacteria by a broth dilution method. 5-Chloropyrazinamide was more active than pyrazinamide against all organisms tested. It is likely that this agent has a different mechanism of action than pyrazinamide.

References

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Citations

Dec 29, 2020·Antimicrobial Agents and Chemotherapy·Elizabeth Story-RollerGyanu Lamichhane
Aug 12, 2015·Antimicrobial Agents and Chemotherapy·Amit KaushikGyanu Lamichhane
Aug 26, 2015·The Journal of Biological Chemistry·Leighanne A Brammer BastaMario A Bianchet
Jul 6, 2002·Organic Letters·Francisco PalaciosRafael López de Munain
Aug 2, 2002·Expert Opinion on Investigational Drugs·Laurent S Kremer, Gurdyal S Besra
Jul 25, 2017·Scientific Reports·Nicholas A DillonAnthony D Baughn
Feb 13, 2019·Antimicrobial Agents and Chemotherapy·Elizabeth Story-RollerGyanu Lamichhane
Dec 10, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jan ZitkoMartin Doležal
Jul 30, 2010·Molecular Diversity·Ahmad ShaabaniAfshin Sarvary
Apr 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Martin JuhásJan Zitko
Apr 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Weronika AmbrożkiewiczJan Zitko
Nov 15, 2006·Antimicrobial Agents and Chemotherapy·Oren ZimhonyWilliam R Jacobs
May 9, 2007·Antimicrobial Agents and Chemotherapy·Silvana C NgoJohn T Welch
Jun 25, 2015·Microbiology Spectrum·Ying ZhangDenis Mitchison
Feb 13, 2007·Bioorganic & Medicinal Chemistry·Yves L Janin

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