In vitro antioxidant activity and antigenotoxicity of 5-n-alkylresorcinols

Journal of Agricultural and Food Chemistry
Kirsti ParikkaKristiina Wähälä

Abstract

Incubation with 5-n-alkylresorcinols (chain lengths C15:0, C17:0, C19:0, C21:0, and C23:0) increased the self-protection capacity of HT29 human colon cancer cells against DNA damage induced by hydrogen peroxide and genotoxic fecal water samples using comet assay (single-cell gel electrophoresis assay). The alkylresorcinols did not exert potent antioxidant activity in the FRAP (ferric reduction ability of plasma) and DPPH (2,2-diphenyl-1-picrylhydrazyl) radical assays. However they were able to significantly inhibit copper-mediated oxidation of human LDL (low-density lipoprotein) in vitro, and pentadecylresorcinol at 25 micromol/L increased lag time by 65 min. The results show that alkylresorcinols have antigenotoxic and antioxidant activity under in vitro conditions.

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Citations

Feb 26, 2008·Analytical and Bioanalytical Chemistry·Matthias KnödlerAndreas Schieber
Jan 10, 2012·Journal of Agricultural and Food Chemistry·Catrin E Tyl, Mirko Bunzel
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