In vitro antioxidant activity and hepatoprotective effects of Lentinula edodes against paracetamol-induced hepatotoxicity.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Sreenivasan SasidharanSanthanam Amutha

Abstract

The objective of this study was to investigate the antioxidant and hepatoprotective effects of methanolic extracts of L. edodes and the determination of their total phenolics content. The amount of total phenolics was estimated to be 70.83 mg Gallic Acid Equivalent (GAE) per gram of dry extract. The antioxidant activity of the L. edodes extract was 39.0% at a concentration of 1 mg/mL and was also concentration dependant, with an EC(50) value of 4.4 mg/mL. Different groups of animals (Wister albino mice) were administered paracetamol (1 g/kg, p.o.). L. edodes extract at a dose of 200 mg/kg was administered to the paracetamol treated mice for seven days. The effects of L. edodes extract on serum transaminases (SGOT, SGPT), alkaline phosphatase (ALP) and bilirubin were measured in the paracetamol-induced hepatotoxic mice. L. edodes extract produced significant (p < 0.05) hepatoprotective effects by decreasing the activity of serum enzymes and bilirubin. From these results, it was suggested that L. edodes extract could perhaps protect liver cells from paracetamol-induced liver damage by its antioxidative effect on hepatocytes, hence diminishing or eliminating the harmful effects of toxic metabolites of paracetamol.

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Citations

Apr 18, 2013·Asian Pacific Journal of Tropical Biomedicine·Badakhshan Mahdi-PourSreenivasan Sasidharan
Dec 18, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Subramanion L JothySreenivasan Sasidharan
Jul 26, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andréia Assunço SoaresRosane Marina Peralta
Nov 28, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Chong Grace-LynnSreenivasan Sasidharan
Dec 8, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kuppan NithiananthamSreenivasan Sasidharan
Dec 15, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Liang FengFeng Shi
Apr 23, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Manal A AbbasSahar M Jaffal
Apr 29, 2018·Journal of Food and Drug Analysis·Mohamed Abdel-DaimIlaria Peluso
May 20, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Gamal A SalemRavi P Sahu

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Methods Mentioned

BETA
RSA

Software Mentioned

SPSS

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