In vitro antioxidant and antinociceptive properties of Porphyra vietnamensis

BioMedicine
Saurabh BhatiaTanveer Naved

Abstract

Current investigation explores the anti-oxidant and antinociceptive potential of edible seaweed namely Porphyra vietnamensis. Radical scavenging and antinociceptive potential of ethanolic (EE), aqueous (AE), acetone (ACE) and chloroform (CE) fractions were determined using various models and assays. Writhing, formalin, hot plate, acetic acid induce response models were performed to determine antinociceptive activity whereas different assays have been used to determine antioxidant potential. Among the various fractions, ACE showed maximum biological activity. In DPPH assay half maximal inhibitory concentration (IC50) was found to be 0.470 ug/ml (DPPH assay), 0.381 jug/m/ (H2O2 assay), 0.470 ug/ml (super oxide assay), 0.591ug/ml (lipid peroxidation) and 0.430 ug/ml (nitric oxide assay). However, comparatively the TPC was more in EE (977.0 mg GAE/gm DW). It was concluded that acetone fraction of Porphyra showed marked antinociceptive and antioxidant activities, however pharmacological and chemical investigations are required to identify principle compounds responsible for activities and characterize their respective mechanism(s) for respective actions.

References

Oct 1, 1982·Analytical Biochemistry·L C GreenS R Tannenbaum
Jan 8, 2004·Biological & Pharmaceutical Bulletin·Pramote MahakunakornHiroshi Watanabe
Jul 31, 2007·Phytochemistry·Phuong Thien ThuongKiHwan Bae
Jan 1, 2010·Pharmacognosy Research·Saurabh BhatiaS Nanda
Mar 19, 2013·International Journal of Biological Macromolecules·Saurabh BhatiaTanmoy Bera
Dec 6, 2014·TheScientificWorldJournal·Saurabh BhatiaTanmoy Bera
Feb 16, 2019·Current Pharmaceutical Design·Vishwas P PardhiRahul Shukla

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Citations

Oct 6, 2021·Environmental Science and Pollution Research International·Saurabh BhatiaCelia Vargas-de-la-Cruz
Oct 30, 2021·Journal of Medicinal Food·Leandro Vinícius Fernandes de MoraisMaria das Graças Almeida

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