In vitro antioxidant and cytotoxic activity of extracts of Baccharis coridifolia DC

Journal of Ethnopharmacology
E MongelliG Ciccia

Abstract

The in vitro antioxidant and cytotoxic activities in different extracts of Baccharis coridifolia DC. (Compositae) were studied using different bioassays. Antioxidant activity was tested using hydroperoxide-initiated chemiluminescence (CL) in rat liver homogenates. The aqueous extract showed antioxidant activity (IC50 = 141 microg/ml), while the dichloromethane and methanol extracts were prooxidant. Activity in the aqueous extract was confirmed by determination of thiobarbituric acid-reactive substances (TBARS), showing an IC50 = 556 microg/ml. On the other hand, studies on the cytotoxic activity demonstrated a 78% crown gall tumour inhibition and an ED50 = 4. 2 microg/ml in KB cells growth for the dichloromethane extract. A 56% decrease in the initial absorbance of DNA-Methyl Green complex could also be observed at 1000 microg/ml, suggesting the presence of compounds that interact with DNA.

References

Nov 1, 1992·Journal of Natural Products·N S BurresJ B McAlpine
Jul 1, 1988·Journal of Natural Products·B B JarvisC S Barros
Jan 1, 1987·Free Radical Biology & Medicine·C G FragaA L Tappel
Mar 1, 1987·Biochemical Pharmacology·C G FragaA Boveris
Jan 1, 1985·Advances in Enzyme Regulation·E Cadenas, H Sies
Nov 1, 1970·Surgery·A T RamirezB R Diño
Jun 23, 1984·Lancet·B Halliwell, J M Gutteridge
Apr 1, 1983·Biochemical Medicine·T YoshikawaM Kondo
Jan 1, 1993·Journal of Natural Products·K LikhitwitayawuidN Ruangrungsi

❮ Previous
Next ❯

Citations

Jul 20, 2002·Journal of Ethnopharmacology·T A Ajith, K K Janardhanan
Sep 30, 2008·Pakistan Journal of Biological Sciences : PJBS·D M T Motlhanka
Aug 11, 2007·Mutation Research·Flávia Aparecida ResendeDenise Crispim Tavares
Jul 9, 2005·Biosensors & Bioelectronics·Lucilene Dornelles MelloLauro Tatsuo Kubota
Jan 16, 2015·Ecotoxicology and Environmental Safety·A P S MenezesA B F Ferraz
Nov 24, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Laura CariddiLiliana Sabini
Jul 12, 2005·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N O A OmisoreJ Watchueng
Jul 27, 2010·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rita R KurdelasMonica L Freile
Jul 14, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Alice NabatanziLyndy J McGaw
Jun 30, 2021·Current Microbiology·Augustin NtemafackSumit G Gandhi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.