In vitro antioxidant effect of Ginkgo biloba extract (EGb 761) on lipoperoxidation induced by hydrogen peroxide in erythrocytes of Behçet's patients

Japanese Journal of Pharmacology
K KöseO Aşçioğlu

Abstract

Excessive superoxide radical production and an impaired antioxidant mechanism in both the neutrophils and plasma of patients with Behçet's disease (BD) have been reported. To provide clinical support for the earlier data, erythrocyte membrane integrity was investigated by measuring malondialdehyde (MDA, a marker of lipid peroxidation) levels in the erythrocytes of BD patients. In addition, the antioxidant effect of Ginkgo biloba extract (EGb 761) at 25 and 250 microg/ml concentrations on lipoperoxidation induced by hydrogen peroxide (H2O2) in erythrocyte obtained from BD patients was examined in in vitro conditions. When compared to healthy controls, basal erythrocyte MDA levels were found to be higher in BD patients. In the in vitro study, there was also a significant increase in H2O2-induced MDA production in the medium containing no EGb 761 in the patient group, whereas significant decreases in MDA levels were observed in the mediums containing EGb 761 both in the patient and control groups. The decrease in MDA production was found to be related to EGb 761 concentration. These data indicate that an oxidative damage is present in erythrocytes obtained from Behçet's patients, and EGb 761, which may strengthen the antioxidant d...Continue Reading

References

Jun 1, 1979·Annals of the Rheumatic Diseases·D W JamesM J Smith
Nov 7, 1992·Lancet·J Kleijnen, P Knipschild
Feb 1, 1990·The New England Journal of Medicine·H YaziciG E Lovatt
Feb 1, 1990·The New England Journal of Medicine·J D O'Duffy
Mar 1, 1988·Biochemical Pharmacology·J Robak, R J Gryglewski
Oct 1, 1987·Annals of Internal Medicine·C E CrossD Harman
Nov 1, 1987·Chemistry and Physics of Lipids·M R Clemens, H D Waller
Dec 1, 1972·British Journal of Haematology·J StocksT L Dormandy
Jan 1, 1971·British Journal of Haematology·J Stocks, T L Dormandy
Feb 1, 1993·Planta medica·O Sticher
Aug 1, 1995·The Tohoku Journal of Experimental Medicine·K KöseO Aşçioğlu

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Citations

Mar 10, 2001·Antioxidants & Redox Signaling·T YoshikawaM Kondo
Oct 22, 2008·Survey of Ophthalmology·M MozaffariehJ Flammer
Jun 24, 2017·Acta ortopedica brasileira·Nizamettin GuzelMurat Topbas
Jul 24, 2004·The British Journal of Dermatology·C YaziciF Ateş
Nov 20, 2004·Phytotherapy Research : PTR·Süreyya Bïlmen SarikçioğluEvren Tercan
Apr 27, 2007·Clinical and Experimental Dermatology·E SezerI Etikan
Jul 5, 2007·Journal of Pediatric Hematology/oncology·Farzaneh Foroughinia, Mehran Karimi
Jan 23, 2009·Journal of Cutaneous Pathology·Ali KaramanFatih Kara
Aug 16, 2002·The Tohoku Journal of Experimental Medicine·Kader KösePakize Doğan
Sep 7, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·R N DavidsonN Benjamin
Jul 2, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·A AkarA R Gur
Jun 22, 2005·Survey of Ophthalmology·Cem Evereklioglu

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